4-methyl-N-pentylaniline

Base Information

• Chemical Name: 4-methyl-N-pentylaniline
• CAS No.: 5417-68-5
• Molecular Formula: C14H13N
• Molecular Weight: 177.29
• Hs Code.: 2921430090
• Mol file: 5417-68-5.mol

Synonyms:p-Toluidine,N-pentyl- (8CI);NSC 7953;4-Methyl-N-pentylaniline;Pentyl-p-tolyl-amine;

Chemical Property of 4-methyl-N-pentylaniline

Chemical Property:

• Vapor Pressure: 0.00582mmHg at 25°C
• Refractive Index: 1.531
• Boiling Point: 273.2 °C at 760 mmHg
• Flash Point: 118.5 °C
• PSA: 12.03000
• Density: 0.927 g/cm³
• LogP: 3.67010

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methyl-N-pentylaniline

There total 4 articles about 4-methyl-N-pentylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-tolyl iodide (624-31-7) + n-Pentylamine (110-58-7) → 4-methyl-N-pentylbenzenamine (5417-68-5)

Guidance literature:

With potassium phosphate; copper(I) bromide; 1,1'-bi-2-naphthol; In N,N-dimethyl-formamide; at 40 ℃; for 8h;

DOI:10.1021/jo062060e

Reference yield: 87.0%

N-(p-tolyl)pentanethioamide (6876-71-7) → 4-methyl-N-pentylbenzenamine (5417-68-5)

Guidance literature:

With 4-dimethylaminopyridine borane; di-tert-butoxydiazene; thiophenol; In toluene; at 80 ℃;

DOI:10.1021/acs.orglett.7b03201

Reference yield: 6.0%

1-Bromopentane (110-53-2) + p-toluidine (106-49-0,12221-03-3) → 4-methyl-N-pentylbenzenamine (5417-68-5)

Guidance literature:

In toluene; for 24h; Heating;

DOI:10.1016/0040-4020(95)00412-2

upstream raw materials:

amyl iodide

p-toluidine

1-Bromopentane

4-tolyl iodide

Refernces

• 1、 Han, Shuang,Zhang, Fei-Fei,Qian, Hai-Yan,Chen, Li-Li,Pu, Jian-Bin,Xie, Xin,Chen, Jian-Zhong. "Development of Quinoline-2,4(1H,3H)-diones as Potent and Selective Ligands of the Cannabinoid Type 2 Receptor". . p. 5751 - 5769. Retrieved 2015/08/24.
• 2、 Wang, Zhe,Fu, Hua,Jiang, Yuyang,Zhao, Yufen. "Iron/copper-cocatalyzed ullmann N,O-arylation using FeCl3, CuO, and rac-1,1′-Binaphthyl-2,2′-diol". body text. p. 2540 - 2546. Retrieved 2009/04/12.