2-AMINO-4-METHOXY-BENZOIC ACID

Base Information

• Chemical Name: 2-AMINO-4-METHOXY-BENZOIC ACID
• CAS No.: 4294-95-5
• Molecular Formula: C8H9NO3
• Molecular Weight: 167.164
• Hs Code.: 29225090
• Mol file: 4294-95-5.mol

Synonyms:p-Anisicacid, 2-amino- (6CI,7CI,8CI);4-Methoxyanthranilic acid;

Chemical Property of 2-AMINO-4-METHOXY-BENZOIC ACID

Chemical Property:

• Vapor Pressure: 3.47E-05mmHg at 25°C
• Melting Point: 174-177 °C
• Refractive Index: 1.603
• Boiling Point: 339.8 °C at 760 mmHg
• PKA: 5.21±0.10(Predicted)
• Flash Point: 159.3 °C
• PSA: 72.55000
• Density: 1.303 g/cm³
• LogP: 1.55680
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-4-methoxybenzoic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-37

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Amino-4-methoxybenzoic Acid, is an organic building block used in the synthesis of various chemical compounds.

Technology Process of 2-AMINO-4-METHOXY-BENZOIC ACID

There total 21 articles about 2-AMINO-4-METHOXY-BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-nitro-4-methoxybenzoic acid (33844-21-2) → 4-methoxyanthranilic acid (4294-95-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 18h; under 760.051 Torr;

Reference yield: 89.0%

methyl 2-amino-4-methoxybenzoate (50413-30-4) → 4-methoxyanthranilic acid (4294-95-5)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; for 5h; Reflux;

DOI:10.1021/acsinfecdis.9b00408

Reference yield: 78.0%

6-methoxyisatin (52351-75-4) → 4-methoxyanthranilic acid (4294-95-5)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; for 24h; Ambient temperature;

upstream raw materials:

6-methoxyisatin

3-amino-4-methylphenol

2-nitro-4-methoxybenzoic acid

2-acetamido-4-methoxybenzoic acid

Downstream raw materials:

2-(3-methoxyphenyl)-1H-isoindole-1,3(2H)-dione

7-methoxyquinazoline-4(3H)-one

2-(carboxymethyl-amino)-4-methoxy-benzoic acid

4-methoxy-2-methylamino-benzoic acid

Refernces

• 1、 Yao, Hong,Uras, Giuseppe,Zhang, Pengfei,Xu, Shengtao,Yin, Ying,Liu, Jie,Qin, Shuai,Li, Xinuo,Allen, Stephanie,Bai, Renren,Gong, Qi,Zhang, Haiyan,Zhu, Zheying,Xu, Jinyi. "Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease". . p. 7483 - 7506. Retrieved 2021/06/28.
• 2、 -. "TREATMENT OF DISEASES BY EPIGENETIC REGULATION". Paragraph 0493; 0494. . Retrieved 2013/11/05.