7-METHOXY-4(1H)-QUINAZOLINONE

Base Information

• Chemical Name: 7-METHOXY-4(1H)-QUINAZOLINONE
• CAS No.: 16064-24-7
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.175
• Hs Code.: 2933990090
• Mol file: 16064-24-7.mol

Synonyms:4(1H)-Quinazolinone,7-methoxy- (9CI);

Chemical Property of 7-METHOXY-4(1H)-QUINAZOLINONE

Chemical Property:

• Melting Point: 257-258℃
• Boiling Point: 338.7 °C at 760 mmHg
• PKA: 1.51±0.20(Predicted)
• Flash Point: 158.7 °C
• PSA: 54.98000
• Density: 1.32 g/cm³
• LogP: 0.93170
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

7-Methoxy-4(3H)-quinazolinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-METHOXY-4(1H)-QUINAZOLINONE

There total 8 articles about 7-METHOXY-4(1H)-QUINAZOLINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ 7-methoxyquinazoline-4(3H)-one (16064-24-7)

Guidance literature:

In 2-methoxy-ethanol; at 100 ℃;

Reference yield: 87.0%

formamidine acetic acid (3473-63-0) + 4-methoxyanthranilic acid (4294-95-5) → 7-methoxyquinazoline-4(3H)-one (16064-24-7)

Guidance literature:

In ethanol; at 120 ℃; for 0.666667h; Microwave irradiation;

DOI:10.1016/j.bmcl.2009.07.075

Reference yield:

4-methoxyanthranilic acid (4294-95-5) + formamidine (463-52-5) → 7-methoxyquinazolin-4-ol (16064-24-7)

Guidance literature:

upstream raw materials:

formic acid

2-amino-p-anisamide

methyl 2-amino-4-methoxybenzoate

formamide

Downstream raw materials:

4-chloro-7-methoxy-quinazoline

7-hydroxyquinazoline-4(3H)-one

Refernces

• 1、 Dung, Do T. M.,Park, Eun J.,Anh, Duong T.,Hai, Pham-The,Huy, Le D.,Jun, Hye W.,Kwon, Joo-Hee,Young Ji,Kang, Jong S.,Tung, Truong T.,Dung, Phan T. P.,Han, Sang-Bae,Nam, Nguyen-Hai. "Design, synthesis, and evaluation of novel (E)-N'-(3-allyl-2-hydroxy)benzylidene-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides as antitumor agents". . . Retrieved 2021/10/25.
• 2、 Sun, Bin,Huang, Panyi,Yan, Zhiyang,Shi, Xiayue,Tang, Xiaoli,Yang, Jin,Jin, Can. "Self-catalyzed phototandem perfluoroalkylation/cyclization of unactivated alkenes: Synthesis of perfluoroalkyl-substituted quinazolinones". supporting information. p. 1026 - 1031. Retrieved 2021/02/06.