2-Amino-4-methoxybenzamide

Base Information

• Chemical Name: 2-Amino-4-methoxybenzamide
• CAS No.: 38487-91-1
• Molecular Formula: C8H10 N2 O2
• Molecular Weight: 166.18
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID60554438
• Nikkaji Number: J218.159B
• Wikidata: Q82435427
• Mol file: 38487-91-1.mol

Synonyms:2-Amino-4-methoxybenzamide;38487-91-1;2-amino-4-methoxy-benzamide;Benzamide, 2-amino-4-methoxy;Benzamide, 2-amino-4-methoxy-;4-methoxy-anthranilamide;4-methoxy-2-aminobenzamide;4-methoxy-2-amino-benzamide;SCHEMBL148855;2-amino-4-(methyloxy)benzamide;DTXSID60554438;MFCD10566483;AKOS006303845;CS-0451983;EN300-872153;F15890

Chemical Property of 2-Amino-4-methoxybenzamide

Chemical Property:

• Vapor Pressure: 0.000447mmHg at 25°C
• Melting Point: 155-155.5 °C
• Boiling Point: 315.1oC at 760 mmHg
• PKA: 16.11±0.50(Predicted)
• Flash Point: 169.7oC
• PSA: 78.34000
• Density: 1.236g/cm3
• LogP: 1.65780
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 166.074227566
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-4-methoxybenzamide ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)C(=O)N)N

Technology Process of 2-Amino-4-methoxybenzamide

There total 8 articles about 2-Amino-4-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-methoxy-2-nitro-benzoic acid amide (33844-22-3) → 2-amino-p-anisamide (38487-91-1)

Guidance literature:

With hydrogen; nickel; In ethanol; at 20 ℃; for 48h; under 2585.81 Torr;

Reference yield: 91.0%

4-methoxyanthranilic acid (4294-95-5) → 2-amino-p-anisamide (38487-91-1)

Guidance literature:

With ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;

Reference yield: 72.0%

6-methoxyisatin (52351-75-4) → 2-amino-p-anisamide (38487-91-1)

Guidance literature:

With ammonium hydroxide; dihydrogen peroxide; In dimethyl sulfoxide; at 20 - 30 ℃; for 4h; Sealed tube;

DOI:10.1016/j.tet.2019.01.067

upstream raw materials:

4-methoxy-2-nitro-benzoic acid amide

4-methoxy-2-nitro-benzonitrile

4-methoxyanthranilic acid

2-nitro-4-methoxybenzoic acid

Downstream raw materials:

ethyl ((2-(aminocarbonyl)-5-methoxyphenyl)amino)(oxo)acetate

4-isopropylthiazole-2-carboxylic acid (2-carbamoyl-5-methoxy-phenyl)-amide

2-amino-4-hydroxybenzamide

2-(2,2-difluoro-2-(4-fluorophenyl)acetamido)-4-methoxybenzamide

Refernces

• 1、 Chen, Xiulei,Zhou, Zhen,Li, Zhong,Xu, Xiaoyong. "Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita". . p. 194 - 200. Retrieved 2019/09/13.
• 2、 Chen, Xiulei,Jia, Haowu,Li, Zhong,Xu, Xiaoyong. "Synthesis and nematicidal evaluation of 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker against Meloidogyne incognita". . p. 1207 - 1213. Retrieved 2019/03/29.