2-(4-Methoxyphenyl)succinic acid

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)succinic acid
• CAS No.: 6331-59-5
• Molecular Formula: C₁₁H₁₂O₅
• Molecular Weight: 224.213
• Hs Code.: 2918990090
• NSC Number: 37769
• DSSTox Substance ID: DTXSID60284581
• Nikkaji Number: J1.409.385K
• Mol file: 6331-59-5.mol

Synonyms:2-(4-Methoxyphenyl)succinic acid;6331-59-5;2-(4-methoxyphenyl)butanedioic acid;2-(4-METHOXY-PHENYL)-SUCCINIC ACID;2-(4-methoxyphenyl)succinicacid;2-(4-Methoxy-phenyl)succinic acid;MFCD00778506;p-Anisyl succinic acid;Oprea1_376113;SCHEMBL7891728;AMY4671;DTXSID60284581;NSC37769;2-(4-Methoxyphenyl)succinic acid #;AB1493;BBL012260;NSC 37769;NSC-37769;STK735145;2-(4-methoxyphenyl)-butanedioic acid;AKOS002130350;AKOS016344010;NS-02769;BB 0254132;CS-0005244;FT-0636098;EN300-704761;A834324;SR-01000102533;SR-01000102533-1;F2189-0986;Z2049991674;24300-05-8

Chemical Property of 2-(4-Methoxyphenyl)succinic acid

Chemical Property:

• Vapor Pressure: 1.11E-05mmHg at 25°C
• Refractive Index: 1.561
• Boiling Point: 355.9 °C at 760 mmHg
• Flash Point: 137 °C
• PSA: 83.83000
• Density: 1.324 g/cm³
• LogP: 1.33810
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 224.06847348
• Heavy Atom Count: 16
• Complexity: 255

Purity/Quality:

99%, ^*data from raw suppliers

2-(4-Methoxyphenyl)succinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(CC(=O)O)C(=O)O

Technology Process of 2-(4-Methoxyphenyl)succinic acid

There total 13 articles about 2-(4-Methoxyphenyl)succinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2,3-dicyano-3-(4-methoxyphenyl)propanoate (75133-95-8) → 2-(4-methoxyphenyl)succinic acid (13565-23-6,38971-62-9,117603-61-9,6331-59-5)

Guidance literature:

With sulfuric acid;

DOI:10.1021/ja01866a053

Reference yield:

2-(4-methoxyphenyl)ethane-1,1,2-tricarbonitrile (22248-24-4) → 2-(4-methoxyphenyl)succinic acid (13565-23-6,38971-62-9,117603-61-9,6331-59-5)

Guidance literature:

With hydrogenchloride;

Reference yield:

ethyl 2,3-dicyano-3-(4-methoxyphenyl)propanoate (75133-95-8) → (+)-(4-methoxy-phenyl)-succinic acid (6331-59-5,13565-23-6,38971-62-9,117603-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous sulfuric acid

With sulfuric acid;

DOI:10.1021/ja01866a053

upstream raw materials:

diethyl-2-(4-methoxybenzylidene)malonate

2-(4-methoxyphenyl)ethane-1,1,2-tricarbonitrile

ethyl 2,3-dicyano-3-(4-methoxyphenyl)propanoate

4-methoxy-benzaldehyde

Downstream raw materials:

3-(4-methoxyphenyl)-pyrrolidine-2,5-dione

2-(4'-hydroxyphenyl)butane-1,4-dioic acid

(+)-(4-methoxy-phenyl)-succinic acid

(-)-(4-methoxy-phenyl)-succinic acid

Refernces