4-BENZOYLPIPERIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 4-BENZOYLPIPERIDINE HYDROCHLORIDE
• CAS No.: 37586-22-4
• Molecular Formula: C12H15NO
• Molecular Weight: 189.257
• Hs Code.: 2933399090
• Mol file: 37586-22-4.mol

Synonyms:4-benzoylpiperidine;4-benzoypiperidine;phenyl(piperidin-4-yl)methanone;methanone, phenyl-4-piperidinyl-;phenyl(piperidin-4-yl)methanone;4- (4-Fluorobenzoyl)-piperidine;Phenyl-piperidin-4-yl-methanone;

Chemical Property of 4-BENZOYLPIPERIDINE HYDROCHLORIDE

Chemical Property:

• Appearance/Colour: White solid
• Melting Point: 226 °C
• Boiling Point: 310.7 °C at 760 mmHg
• Flash Point: 125.3 °C
• PSA: 29.10000
• Density: 1.054 g/cm³
• LogP: 2.19770
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

Phenyl(piperidin-4-yl)methanone 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BENZOYLPIPERIDINE HYDROCHLORIDE

There total 5 articles about 4-BENZOYLPIPERIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-benzoyl-4-benzoylpiperidine (109555-51-3) → 4-benzoylpiperidine (37586-22-4)

Guidance literature:

With hydrogenchloride; water; Reflux; Inert atmosphere;

DOI:10.1021/jm8012344

Reference yield: 80.0%

1-(4-benzoylpiperidin-1-yl)ethanone (25519-79-3) → 4-benzoylpiperidine (37586-22-4)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 90 ℃;

DOI:10.1021/acs.jmedchem.8b01483

Reference yield:

4-benzylpyperidine (31252-42-3) → phenyl-piperidin-4-yl-methanol (38081-60-6) + 4-benzoylpiperidine (37586-22-4)

Guidance literature:

With dipotassium peroxodisulfate; sulfuric acid; In water; at 80 ℃; for 4h; Reagent/catalyst; Solvent; Sealed tube;

DOI:10.1021/acs.orglett.6b03731

upstream raw materials:

1-(4-benzoylpiperidin-1-yl)ethanone

1-benzoyl-4-benzoylpiperidine

4-piperidinylcarbonyl chloride

benzene

Downstream raw materials:

1-(t-butoxycarbonyl)-4-(benzoyl)piperidine

phenyl-piperidin-4-yl-methanol

[1-(2-Amino-4,5-dihydro-oxazol-5-ylmethyl)-piperidin-4-yl]-phenyl-methanone

1-benzoyl-4-benzoylpiperidine

Refernces

• 1、 Lee, Melissa,Sanford, Melanie S.. "Remote C(sp3)-H Oxygenation of Protonated Aliphatic Amines with Potassium Persulfate". supporting information. p. 572 - 575. Retrieved 2017/02/10.
• 2、 Pajouhesh, Hassan,Feng, Zhong-Ping,Ding, Yanbing,Zhang, Lingyun,Pajouhesh, Hossein,Morrison, Jerrie-Lynn,Belardetti, Francesco,Tringham, Elizabeth,Simonson, Eric,Vanderah, Todd W.,Porreca, Frank,Zamponi, Gerald W.,Mitscher, Lester A.,Snutch, Terrance P.. "Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors". scheme or table. p. 1378 - 1383. Retrieved 2010/07/06.