PHENYL-PIPERIDIN-4-YL-METHANOL

Base Information

• Chemical Name: PHENYL-PIPERIDIN-4-YL-METHANOL
• CAS No.: 38081-60-6
• Molecular Formula: C12H17NO
• Molecular Weight: 191.273
• Hs Code.: 2933399090
• Mol file: 38081-60-6.mol

Synonyms:α-Phenyl-4-piperidinemethanol;

Chemical Property of PHENYL-PIPERIDIN-4-YL-METHANOL

Chemical Property:

• Vapor Pressure: 6E-05mmHg at 25°C
• Refractive Index: 1.55
• Boiling Point: 332 °C at 760 mmHg
• Flash Point: 130.8 °C
• PSA: 32.26000
• Density: 1.068 g/cm³
• LogP: 2.04840

Purity/Quality:

95-99% ^*data from raw suppliers

phenyl(piperidin-4-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PHENYL-PIPERIDIN-4-YL-METHANOL

There total 11 articles about PHENYL-PIPERIDIN-4-YL-METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Benzoylpyridine (14548-46-0) → phenyl-piperidin-4-yl-methanol (38081-60-6)

Guidance literature:

With hydrogen; acetic acid; platinum(IV) oxide; In ethanol; for 16h; under 3102.97 Torr; Product distribution / selectivity;

Reference yield: 94.0%

3-bromo-α-phenyl-4-pyridinemethanol (234111-13-8) → phenyl-piperidin-4-yl-methanol (38081-60-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; at 80 ℃; for 18h; under 22502.3 Torr; Autoclave;

DOI:10.1002/ejoc.201900450

Reference yield: 90.0%

4-benzoylpiperidine (37586-22-4) → phenyl-piperidin-4-yl-methanol (38081-60-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; water; Heating;

DOI:10.1021/jm0309349

upstream raw materials:

phenyl-[4]pyridyl ketone; hydrochloride

4-benzoylpiperidine

4-Benzoylpyridine

1-(4-benzoylpiperidin-1-yl)ethanone

Downstream raw materials:

N-[4-(α-hydroxy-benzyl)-piperidinomethyl]-phthalimide

(1-methylpiperidin-4-yl)(phenyl)methanol

(4-(hydroxy(phenyl)methyl)piperidin-1-yl)(phenyl)methanone

1-(4-{3-[4-(Hydroxy-phenyl-methyl)-piperidin-1-yl]-propoxy}-3-methoxy-phenyl)-ethanone

Refernces

• 1、 Lee, Melissa,Sanford, Melanie S.. "Remote C(sp3)-H Oxygenation of Protonated Aliphatic Amines with Potassium Persulfate". supporting information. p. 572 - 575. Retrieved 2017/02/10.
• 2、 Pajouhesh, Hassan,Feng, Zhong-Ping,Ding, Yanbing,Zhang, Lingyun,Pajouhesh, Hossein,Morrison, Jerrie-Lynn,Belardetti, Francesco,Tringham, Elizabeth,Simonson, Eric,Vanderah, Todd W.,Porreca, Frank,Zamponi, Gerald W.,Mitscher, Lester A.,Snutch, Terrance P.. "Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors". scheme or table. p. 1378 - 1383. Retrieved 2010/07/06.