6-Hydrazinoimidazo[1,2-b]pyridazine

Base Information

• Chemical Name: 6-Hydrazinoimidazo[1,2-b]pyridazine
• CAS No.: 6653-91-4
• Molecular Formula: C6H7N5
• Molecular Weight: 149.1533
• Hs Code.: 2933990090
• Mol file: 6653-91-4.mol

Synonyms:imidazo[1,2-b]pyridazin-6-yl-hydrazine;6-Hydrazinoimidazo[1,2-b]pyridazine;6-hydrazinoimidazo[4,3-b]pyridazine;6-hydrazinoimidazol[1,2-b]pyridazine;

Chemical Property of 6-Hydrazinoimidazo[1,2-b]pyridazine

Chemical Property:

• Melting Point: 225 °C
• Boiling Point: °Cat760mmHg
• PKA: 3.73±0.20(Predicted)
• Flash Point: °C
• PSA: 68.24000
• Density: 1.59g/cm³
• LogP: 0.78820

Purity/Quality:

98%min ^*data from raw suppliers

6-Hydrazinoimidazo[1,2-b]pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Hydrazinoimidazo[1,2-b]pyridazine

There total 2 articles about 6-Hydrazinoimidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-chloroimidazo[1,2-b]pyridazine (6775-78-6) → 6-hydrazinoimidazol[1,2-b]pyridazine (6653-91-4)

Guidance literature:

With hydrazine hydrate; for 1h; Reflux;

Reference yield:

→ 6-hydrazinoimidazol[1,2-b]pyridazine (6653-91-4)

Guidance literature:

DOI:10.1016/S0040-4039(00)75666-8 DOI:10.1016/S0040-4020(01)83324-X

Reference yield: 100.0%

(3E)-1-benzoyl-3-(dimethylamino)methylidenepyrrolidin-2-one (958462-15-2) + 6-hydrazinoimidazol[1,2-b]pyridazine (6653-91-4) → N-{2-[2-(imidazo[1,2-b]pyridazin-6-yl)-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]ethyl}benzamide (958462-35-6)

Guidance literature:

With hydrogenchloride; In propan-1-ol; for 4h; Heating;

DOI:10.1016/j.tet.2007.07.052

upstream raw materials:

6-chloroimidazo[1,2-b]pyridazine

Downstream raw materials:

N-{2-[2-(imidazo[1,2-b]pyridazin-6-yl)-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]ethyl}benzamide

imidazo[1.2-b]pyridazine

Refernces

• 1、 -. "Deuterated acetylene derivatives, its pharmaceutical composition and application". Paragraph 0150; 0152; 0153; 0154. . Retrieved 2018/11/22.