Imidazo[1,2-b]pyridazine

Base Information

• Chemical Name: Imidazo[1,2-b]pyridazine
• CAS No.: 766-55-2
• Molecular Formula: C6H5N3
• Molecular Weight: 119.126
• Hs Code.: 29335990
• Mol file: 766-55-2.mol

Synonyms:1,3a,4-Triazaindene;1,5-Diazaindolizine;

Chemical Property of Imidazo[1,2-b]pyridazine

Chemical Property:

• Appearance/Colour: Pale yellow to almost white crystalline powder
• Melting Point: 53 - 55oC
• Refractive Index: 1.689
• PKA: 5.30±0.30(Predicted)
• PSA: 30.19000
• Density: 1.29 g/cm³
• LogP: 0.72930
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Soluble in dimethylformamide.

Purity/Quality:

99% ^*data from raw suppliers

Imidazo[1,2]pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Imidazo[1,2-b]pyridazine is used as an intermediate of cefozopran, building block and in fused ring systems.

Technology Process of Imidazo[1,2-b]pyridazine

There total 6 articles about Imidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-aminopyridazine (5469-70-5) + 2-chloroethanal (107-20-0) → imidazo[1.2-b]pyridazine (766-55-2)

Guidance literature:

at 70 ℃;

DOI:10.1021/acs.jmedchem.0c02064

Reference yield: 87.0%

6-chloroimidazo[1,2-b]pyridazine (6775-78-6) → imidazo[1.2-b]pyridazine (766-55-2)

Guidance literature:

With palladium on activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; methanol; for 16h;

Reference yield:

2H-Pyridazin-3-one (504-30-3) + 2-chloroethanamine hydrochloride (870-24-6) → imidazo[1.2-b]pyridazine (766-55-2)

Guidance literature:

With sodium sulfate; triethylamine; In chloroform; at 20 - 60 ℃; for 5h;

upstream raw materials:

C₈H₉N₅O

6-hydrazinoimidazol[1,2-b]pyridazine

3-aminopyridazine

2-chloroethanal

Downstream raw materials:

C₃₁H₂₈F₂N₅O₆S⁽¹⁺⁾*I^(1-)

C₃₆H₃₁ClN₅O₆S⁽¹⁺⁾*I^(1-)

C₃₆H₃₀Cl₂N₅O₆S⁽¹⁺⁾*I^(1-)

Refernces

• 1、 Juillet, Charlotte,Ermolenko, Ludmila,Boyarskaya, Dina,Baratte, Blandine,Josselin, Béatrice,Nedev, Hristo,Bach, Stéphane,Iorga, Bogdan I.,Bignon, Jér?me,Ruchaud, Sandrine,Al-Mourabit, Ali. "From Synthetic Simplified Marine Metabolite Analogues to New Selective Allosteric Inhibitor of Aurora B Kinase". . p. 1197 - 1219. Retrieved 2021/02/05.
• 2、 -. "Method for synthesizing 3-bromoimidazo[1,2-b]pyrazine". Paragraph 0024. . Retrieved 2016/12/01.