1-Methoxy-4-{[(4-methoxyphenyl)methyl]sulfanyl}benzene

Base Information

• Chemical Name: 1-Methoxy-4-{[(4-methoxyphenyl)methyl]sulfanyl}benzene
• CAS No.: 5023-73-4
• Molecular Formula: C15H16O2S
• Molecular Weight: 260.357
• DSSTox Substance ID: DTXSID50488672
• Nikkaji Number: J1.062.707I
• Wikidata: Q82331481
• Mol file: 5023-73-4.mol

Synonyms:5023-73-4;SCHEMBL3228582;1-Methoxy-4-{[(4-methoxyphenyl)methyl]sulfanyl}benzene;DTXSID50488672

Chemical Property of 1-Methoxy-4-{[(4-methoxyphenyl)methyl]sulfanyl}benzene

Chemical Property:

• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 260.08710092
• Heavy Atom Count: 18
• Complexity: 219

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CSC2=CC=C(C=C2)OC

Technology Process of 1-Methoxy-4-{[(4-methoxyphenyl)methyl]sulfanyl}benzene

There total 10 articles about 1-Methoxy-4-{[(4-methoxyphenyl)methyl]sulfanyl}benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-Methoxybenzenethiol (696-63-9) + 4-Methoxybenzyl alcohol (105-13-5) → 4-methoxybenzyl-(4'-methoxyphenyl)-sulfide (5023-73-4)

Guidance literature:

With oxygen; 9-(2-mesityl)-10-methylacridinium perchlorate; In acetonitrile; at 30 - 35 ℃; for 24h; Schlenk technique; Irradiation;

DOI:10.1039/d0cc02352c

Reference yield: 92.0%

para-iodoanisole (696-62-8) + p-methoxybenzylmercaptan (6258-60-2) → 4-methoxybenzyl-(4'-methoxyphenyl)-sulfide (5023-73-4)

Guidance literature:

With trans-9,10-dihydro-9,10-ethanoanthracene-11,12-dimethanol; caesium carbonate; copper(I) bromide; In acetonitrile; at 82 ℃; for 15h; Inert atmosphere; Sealed tube;

DOI:10.1055/s-0029-1217056

Reference yield: 86.0%

4-Methoxybenzenethiol (696-63-9) + p-methoxybenzyl chloride (824-94-2) → 4-methoxybenzyl-(4'-methoxyphenyl)-sulfide (5023-73-4)

Guidance literature:

With cesium fluoride; In acetonitrile; at 82 ℃;

DOI:10.1016/S0040-4039(02)02028-2 DOI:10.1007/s00706-005-0351-6

upstream raw materials:

4-Methoxybenzenethiol

p-methoxybenzyl chloride

4-Methoxybenzyl alcohol

4-methoxybenzenesulfonic acid

Downstream raw materials:

(R)-4-methoxyphenyl 4-methoxybenzyl sulfoxide

4-methoxyphenyl 4-methoxybenzyl sulfoxide

4-(4-hydroxybenzylthio)phenol

(4-methoxyphenyl)(1-(4-methoxyphenyl)butyl)sulfane

Refernces

• 1、 Murai, Toshiaki,Morikawa, Kenta,Maruyama, Toshifumi. "Sequential one-pot addition of excess aryl-grignard reagents and electrophiles to O-alkyl thioformates". . p. 13112 - 13119. Retrieved 2013/10/01.
• 2、 Prasad,Sekar, Govindasamy. "An efficient, mild and intermolecular ullmann-type synthesis of thioethers catalyzed by a diol-copper(I) complex". experimental part. p. 79 - 84. Retrieved 2010/06/15.