Methyl 6-Methoxy-2-naphthoate

Base Information

• Chemical Name: Methyl 6-Methoxy-2-naphthoate
• CAS No.: 5043-02-7
• Molecular Formula: C13H12O3
• Molecular Weight: 216.236
• Hs Code.: 2918990090
• Mol file: 5043-02-7.mol

Synonyms:Methyl 6-methoxy-2-naphthoate;6-methoxy-[2]naphthoic acid methyl ester;6-Methoxy-[2]naphthoesaeure-methylester;methyl 6-methoxy-1,2,3,4-tetrahydro-2-naphthoate;6-methoxy-naphthalene-2-carboxylic acid methyl ester;Methyl 2-naphthoate,6-methoxy;2-methoxy-6-(methoxycarbonyl)naphthalene;

Chemical Property of Methyl 6-Methoxy-2-naphthoate

Chemical Property:

• Melting Point: 128-129 °C
• Boiling Point: 344.1±15.0 °C(Predicted)
• PSA: 35.53000
• Density: 1.166±0.06 g/cm3(Predicted)
• LogP: 2.63500

Purity/Quality:

95% ^*data from raw suppliers

Methyl 6-methoxy-2-naphthoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 6-Methoxy-2-naphthoate

There total 13 articles about Methyl 6-Methoxy-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

6-Hydroxy-2-naphthoic acid (16712-64-4) → 6-methoxy-2-naphthoic acid methyl ester (5043-02-7)

Guidance literature:

With dimethyl sulfate; In sodium hydroxide;

Reference yield: 94.0%

methanol (67-56-1) + 2-methoxy-6-naphthoic acid (2471-70-7) → 6-methoxy-2-naphthoic acid methyl ester (5043-02-7)

Guidance literature:

sulfuric acid; at 80 ℃; for 8h;

Reference yield: 85.0%

methanol (67-56-1) + 4-Phenoxybenzoic acid (2215-77-2) → 6-methoxy-2-naphthoic acid methyl ester (5043-02-7)

Guidance literature:

With sulfuric acid; Heating;

upstream raw materials:

methanol

2-methoxy-6-naphthoic acid

4-Phenoxybenzoic acid

3,3-Dimethoxy-2-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-butyric acid methyl ester

Downstream raw materials:

(6-methoxy-2-naphthyl)methanol

2-(chloromethyl)-6-methoxynaphthalene

2-methoxy-6-naphthoic acid

6-(phenyl)-2-naphthoic acid methyl ester

Refernces

• 1、 Natte, Kishore,Dumrath, Andreas,Neumann, Helfried,Beller, Matthias. "Palladium-catalyzed carbonylations of aryl bromides using paraformaldehyde: Synthesis of aldehydes and esters". supporting information. p. 10090 - 10094. Retrieved 2015/03/31.
• 2、 -. "ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS". Page/Page column 140. . Retrieved 2010/04/03.