Technology Process of 5-hexylbenzene-1,3-diol
There total 13 articles about 5-hexylbenzene-1,3-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
2: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
3: NaI, ClSiMe3 / acetonitrile / 36 h / Heating
With
chloro-trimethyl-silane; sulfuric acid; hydrogen; magnesium; sodium iodide; methyl iodide;
palladium on activated charcoal;
In
diethyl ether; ethyl acetate; acetonitrile;
DOI:10.1016/S0031-9422(00)80159-4
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 89 percent / (COCl)2 / benzene / 2 h, room t., 1 h, reflux
2: 70 percent / NaOAc, H2 / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight
3: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
4: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
5: NaI, ClSiMe3 / acetonitrile / 36 h / Heating
With
chloro-trimethyl-silane; oxalyl dichloride; sulfuric acid; hydrogen; sodium acetate; magnesium; sodium iodide; methyl iodide;
palladium on activated charcoal;
In
diethyl ether; ethyl acetate; acetonitrile; benzene;
DOI:10.1016/S0031-9422(00)80159-4
