Phosphoric acid, diethyl 4-methoxyphenyl ester

Base Information

• Chemical Name: Phosphoric acid, diethyl 4-methoxyphenyl ester
• CAS No.: 5076-68-6
• Molecular Formula: C11H17O5P
• Molecular Weight: 260.227
• Mol file: 5076-68-6.mol

Synonyms:phosphoric acid, diethyl 4-methoxyphenyl ester-;(4-methoxyphenyl)diethylphosphate;(4-methoxyphenyl)diethyl phosphate;O,O-diethyl O-(4-methoxyphenyl)-phosphate;Phosphoric acid diethyl ester 4-methoxy-phenyl ester;4-methoxyphenyl diethyl phosphate;(4-methoxyphenyl) diethyl phosphate;

Chemical Property of Phosphoric acid, diethyl 4-methoxyphenyl ester

Chemical Property:

• Boiling Point: 125-130 °C(Press: 0.1 Torr)
• PSA: 63.80000
• Density: 1.162±0.06 g/cm3(Predicted)
• LogP: 3.25510

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid, diethyl 4-methoxyphenyl ester

There total 12 articles about Phosphoric acid, diethyl 4-methoxyphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-methoxyphenyl triflate (66107-29-7) + diethyl phosphite potassium salt (54058-00-3) → diethyl 4-methoxyphenyl phosphate (5076-68-6) + 4-methoxy-phenol (150-76-5)

Guidance literature:

In ammonia; at -33 ℃; for 18h;

DOI:10.1021/jo00165a019

Reference yield: 90.0%

diethyl chlorophosphate (814-49-3) + 4-methoxy-phenol (150-76-5) → diethyl 4-methoxyphenyl phosphate (5076-68-6)

Guidance literature:

With triethylamine;

Reference yield: 89.0%

triethyl phosphate (78-40-0) + 4-methoxy-phenol (150-76-5) → diethyl 4-methoxyphenyl phosphate (5076-68-6)

Guidance literature:

triethyl phosphate; With pyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at 20 ℃; for 0.166667h;

4-methoxy-phenol; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/acs.orglett.8b02073

upstream raw materials:

4-methoxyphenyl phosphorodichloridate

sodium 4-methoxyphenolate

diethyl chlorophosphate

4-methoxy-phenol

Downstream raw materials:

(4-methoxy-benzyl)-trimethyl-silane

diethyl ether of 2-hydroxy-5-methoxyphenylphosphonic acid

Diethyl phosphate

4-chloromethoxybenzene

Refernces

• 1、 Ash, Jeffrey,Cordero, Paula,Huang, Hai,Kang, Jun Yong. "Selective hydrolysis of phosphorus(v) compounds to form organophosphorus monoacids". . p. 6007 - 6014. Retrieved 2021/07/21.
• 2、 Anitha, Thippani,Ashalu, Kashamalla Chinna,Sandeep, Mummadi,Mohd, Aabid,Wencel-Delord, Joanna,Colobert, Francoise,Reddy, Kallu Rajender. "LiI/TBHP Mediated Oxidative Cross-Coupling of P(O)–H Compounds with Phenols and Various Nucleophiles: Direct Access to the Synthesis of Organophosphates". . p. 7463 - 7474. Retrieved 2019/12/03.