Technology Process of (6aR,10aR)-1-hydroxy-6,6-dimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromene-9-carbaldehyde
There total 12 articles about (6aR,10aR)-1-hydroxy-6,6-dimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromene-9-carbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium carbonate; lithium bromide;
In
N,N-dimethyl-formamide;
at 100 ℃;
for 6h;
DOI:10.1139/v82-403
- Guidance literature:
-
With
boron trifluoride diethyl etherate; mercury(II) oxide;
In
dichloromethane; water;
for 1h;
Yield given;
Ambient temperature;
DOI:10.1021/jo00024a031
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) n-BuLi / 1) THF, hexane, -30 deg C, 1.5 h, 2) THF, room temperature, 0.5 h
2: 19 percent / p-TosOH*H2O / benzene / 0.25 h / 85 - 90 °C
3: HgO, BF3*Et2O / CH2Cl2; H2O / 1 h / Ambient temperature
With
n-butyllithium; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; mercury(II) oxide;
In
dichloromethane; water; benzene;
DOI:10.1021/jo00024a031
