2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE

Base Information

• Chemical Name: 2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE
• CAS No.: 5221-37-4
• Molecular Formula: C7H7ClN2O
• Molecular Weight: 170.598
• Hs Code.: 2933399090
• Mol file: 5221-37-4.mol

Synonyms:Pyridine,2-(2-chloroacetamido)- (6CI,7CI,8CI);2-(Chloroacetamido)pyridine;2-(Chloroacetylamino)pyridine;2-Chloro-N-2-pyridinylacetamide;NSC 151214;NSC505701;

Chemical Property of 2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE

Chemical Property:

• Vapor Pressure: 6.43E-06mmHg at 25°C
• Melting Point: 110 °C
• Refractive Index: 1.599
• Boiling Point: 378.1 °C at 760 mmHg
• PKA: 11.59±0.70(Predicted)
• Flash Point: 182.5 °C
• PSA: 41.99000
• Density: 1.341 g/cm³
• LogP: 1.33190
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-N-pyridin-2-ylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE

There total 5 articles about 2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-aminopyridine (504-29-0) + chloroacetyl chloride (79-04-9) → 2-chloro-N-pyridin-2-ylacetamide (5221-37-4)

Guidance literature:

2-aminopyridine; chloroacetyl chloride; In 1,2-dichloro-ethane; at 80 ℃; for 0.0833333h; Microwave irradiation;

With sodium hydroxide; In water; 1,2-dichloro-ethane;

Reference yield: 80.0%

2-aminopyridine (504-29-0) + chloroacetic acid (79-11-8) → 2-chloro-N-pyridin-2-ylacetamide (5221-37-4)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 40 ℃; for 2h; Inert atmosphere;

DOI:10.1071/CH14714

Reference yield:

N-(2-pyridyl)diphenylacetamide (94258-23-8) → 2-chloro-N-pyridin-2-ylacetamide (5221-37-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 600 °C / 0 - 0 Torr

2: dicyclohexyl-carbodiimide / dichloromethane / 2 h / 40 °C / Inert atmosphere

With dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1071/CH14714

upstream raw materials:

2-aminopyridine

chloroacetyl chloride

N-(2-pyridyl)diphenylacetamide

chloroacetic acid

Downstream raw materials:

2-[4-N-(o-methoxyphenyl)aminopiperidinyl]-N-pyridin-2-ylacetamide

2-(4-benzylpiperazin-1-yl)-N-pyridin-2-ylacetamide

8-[3-((2-[4-(2-methoxyphenyl)piperazine-1-yl]-ethyl)pyridine-2-yl-amino)propyl]-[1,2,5,8]dithiadiazecan-6-one

1-(2-methoxyphenyl)-4-(2-(2-pyridylamino)ethyl)piperazine

Refernces

• 1、 Bulitta, Jürgen B.,Dharuman, Suresh,Lee, Richard E.,Reeve, Stephanie M.,Wallace, Miranda J.. "Synthesis and Structure–Activity Relationship of Thioacetamide-Triazoles against Escherichia coli". . . Retrieved 2022/03/01.
• 2、 Haverkate, Natalie A.,van Rensburg, Michelle,Kumara, Sisira,Reynisson, Jóhannes,Leung, Euphemia,Pilkington, Lisa I.,Barker, David. "Improving the solubility of anti-proliferative thieno[2,3-b]quinoline-2-carboxamides". supporting information. . Retrieved 2021/03/16.