2,2-diphenyl-N-(pyridin-2-yl)acetamide

Base Information

• Chemical Name: 2,2-diphenyl-N-(pyridin-2-yl)acetamide
• CAS No.: 94258-23-8
• Molecular Formula: C19H16 N2 O
• Molecular Weight: 288.349
• NSC Number: 59151
• DSSTox Substance ID: DTXSID60915863
• Wikidata: Q82886932
• ChEMBL ID: CHEMBL2133656
• Mol file: 94258-23-8.mol

Synonyms:94258-23-8;NSC59151;Oprea1_514883;Oprea1_636887;MLS001163755;CHEMBL2133656;DTXSID60915863;NSC-59151;STK731684;AKOS003670274;2,2-diphenyl-N-(pyridin-2-yl)acetamide;SMR000539224;2,2-Diphenyl-N-(pyridin-2-yl)ethanimidic acid;SR-01000411981;SR-01000411981-1;Z60744781

Chemical Property of 2,2-diphenyl-N-(pyridin-2-yl)acetamide

Chemical Property:

• Vapor Pressure: 3.02E-11mmHg at 25°C
• Boiling Point: 528.3°C at 760 mmHg
• Flash Point: 273.3°C
• Density: 1.2g/cm³
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 288.126263138
• Heavy Atom Count: 22
• Complexity: 327

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC3=CC=CC=N3

Technology Process of 2,2-diphenyl-N-(pyridin-2-yl)acetamide

There total 4 articles about 2,2-diphenyl-N-(pyridin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-aminopyridine (504-29-0) + 2,2-diphenylacetic acid (117-34-0) → N-(2-pyridyl)diphenylacetamide (94258-23-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 40 ℃; for 2h; Inert atmosphere;

DOI:10.1071/CH14714

Reference yield:

3,3-diphenyl-1-[2]pyridyl-azetidine-2,4-dione (111796-64-6) → N-(2-pyridyl)diphenylacetamide (94258-23-8)

Guidance literature:

With sodium carbonate;

DOI:10.1002/hlca.19590420336

Reference yield:

2-aminopyridine (504-29-0) → N-(2-pyridyl)diphenylacetamide (94258-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: aq.-ethanolic acetic acid

With pyridine; acetic acid;

DOI:10.1002/hlca.19590420336

upstream raw materials:

2-aminopyridine

diphenylacetic acid chloride

3,3-diphenyl-1-[2]pyridyl-azetidine-2,4-dione

2,2-diphenylacetic acid

Downstream raw materials:

2-chloro-N-pyridin-2-ylacetamide

2-cyano-N-(pyridin-2-yl)acetamide

2-aminopyridine

diphenyl ketene

Refernces