2-FLUOROPHENOXYACETIC ACID

Base Information

• Chemical Name: 2-FLUOROPHENOXYACETIC ACID
• CAS No.: 348-10-7
• Molecular Formula: C8H7 F O3
• Molecular Weight: 170.14
• Hs Code.: 2918990090
• Mol file: 348-10-7.mol

Synonyms:Aceticacid, (2-fluorophenoxy)- (9CI); Acetic acid, (o-fluorophenoxy)- (7CI,8CI);2-(2-Fluorophenoxy)acetic acid; 2-Fluorophenoxyacetic acid; NSC 10232;o-Fluorophenoxyacetic acid

Chemical Property of 2-FLUOROPHENOXYACETIC ACID

Chemical Property:

• Vapor Pressure: 0.00103mmHg at 25°C
• Melting Point: 139 °C(Solv: benzene (71-43-2))
• Boiling Point: 289.2°Cat760mmHg
• PKA: 3.10±0.10(Predicted)
• Flash Point: 128.7°C
• PSA: 46.53000
• Density: 1.321g/cm³
• LogP: 1.28910
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

(2-Fluorophenoxy)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUOROPHENOXYACETIC ACID

There total 6 articles about 2-FLUOROPHENOXYACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium; (2-fluoro-phenoxy)-acetate → (2-fluorophenoxy)acetic acid (348-10-7)

Guidance literature:

With hydrogenchloride; In water; pH=1;

DOI:10.1016/j.bmcl.2015.10.041

Reference yield:

ethyl 2-(4-fluorophenoxy)acetate (2248-56-8) → (2-fluorophenoxy)acetic acid (348-10-7)

Guidance literature:

With sodium hydroxide; In acetone; at 20 ℃; for 2h;

DOI:10.1016/j.jfluchem.2005.11.013

Reference yield:

2-fluorophenol (367-12-4) + chloroacetic acid (79-11-8) → (2-fluorophenoxy)acetic acid (348-10-7)

Guidance literature:

With sodium hydroxide; at 100 ℃;

DOI:10.1021/ja01248a031

upstream raw materials:

2-fluorophenol

chloroacetic acid

2-fluorophenolate anion

ethyl 2-(4-fluorophenoxy)acetate

Downstream raw materials:

2-(2-Fluoro-phenoxy)-N-(3-isopropoxy-propyl)-acetamide

<2-Fluor-phenoxy>-acetylchlorid

2-{[(2-fluorophenyl)oxy]acetyl}hydrazinecarbonylthioamide

O,O-dimethyl α-(2-fluorophenoxyacetoxy)ethylphosphonate

Refernces

• 1、 Wang, Tao,Wang, Wei,Peng, Hao,He, Hongwu. "Synthesis and biological activity of 1-(Substituted phenoxyacetoxy)- 1-(pyridin-2-yl or thien-2-yl)methylphosphonates". . p. 173 - 179. Retrieved 2015/01/30.
• 2、 Deng, Xiaoyan,Liao, Guihong,Long, Qingwu,Gao, Yujiao,Peng, Hao,He, Hongwu. "Synthesis and herbicidal activity of [(Substituted Phenoxyacetoxy) (Substituted Phenyl)Methyl](Methyl) phosphinates containing fluorine". . p. 663 - 671. Retrieved 2013/07/26.