3,4-Dihydro-6,7-dimethoxy-3-methylisoquinoline hydrochloride

Base Information

• Chemical Name: 3,4-Dihydro-6,7-dimethoxy-3-methylisoquinoline hydrochloride
• CAS No.: 5884-29-7
• Molecular Formula: C12H16ClNO2
• Molecular Weight: 241.7139
• Mol file: 5884-29-7.mol

Synonyms:NSC 36394;3,4-Dihydro-6,7-dimethoxy-3-methylisoquinoline hydrochloride;ISOQUINOLINE, 3,4-DIHYDRO-6,7-DIMETHOXY-3-METHYL-, HYDROCHLORIDE;LS-85535

Chemical Property of 3,4-Dihydro-6,7-dimethoxy-3-methylisoquinoline hydrochloride

Chemical Property:

• Vapor Pressure: 0.000375mmHg at 25°C
• Boiling Point: 327.9°Cat760mmHg
• Flash Point: 124.3°C
• PSA: 30.82000
• Density: g/cm³
• LogP: 2.30490
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 241.0869564
• Heavy Atom Count: 16
• Complexity: 242

Purity/Quality:

99% ^*data from raw suppliers

6,7-DIMETHOXY-3-METHYL-3,4-DIHYDROISOQUINOLINE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CC2=CC(=C(C=C2C=[NH+]1)OC)OC.[Cl-]

Technology Process of 3,4-Dihydro-6,7-dimethoxy-3-methylisoquinoline hydrochloride

There total 4 articles about 3,4-Dihydro-6,7-dimethoxy-3-methylisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3,4-dimethoxyphenyl)-2-methylpropanoic acid (53979-33-2) → 6,7-dimethoxy-3-methyl-3,4-dihydro-isoquinoline; hydrochloride (5884-29-7)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride; sodium hydroxide; aqueous ammonia

2: dioxane; aqueous sodium hypochlorite

3: 210 °C / und Erhitzen des erhaltenen N-<2-(3,4-Dimethoxy-phenyl)-1-methyl-aethyl>-formamids mit Phosphorylchlorid und Toluol

With 1,4-dioxane; ammonium hydroxide; sodium hydroxide; sodium hypochlorite; thionyl chloride;

DOI:10.1021/ja01859a050

Reference yield:

3-(3,4-dimethoxy-phenyl)-2-methyl-propionic acid amide (106273-88-5) → 6,7-dimethoxy-3-methyl-3,4-dihydro-isoquinoline; hydrochloride (5884-29-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dioxane; aqueous sodium hypochlorite

2: 210 °C / und Erhitzen des erhaltenen N-<2-(3,4-Dimethoxy-phenyl)-1-methyl-aethyl>-formamids mit Phosphorylchlorid und Toluol

With 1,4-dioxane; sodium hypochlorite;

DOI:10.1021/ja01859a050

Reference yield:

formic acid (64-18-6) + 2-(3,4-dimethoxyphenyl)-1-methylethylamine (120-26-3) → 6,7-dimethoxy-3-methyl-3,4-dihydro-isoquinoline; hydrochloride (5884-29-7)

Guidance literature:

at 210 ℃; und Erhitzen des erhaltenen N-<2-(3,4-Dimethoxy-phenyl)-1-methyl-aethyl>-formamids mit Phosphorylchlorid und Toluol;

DOI:10.1021/ja01859a050

upstream raw materials:

formic acid

2-(3,4-dimethoxyphenyl)-1-methylethylamine

formamide

Methylisoeugenol