2-Propenoic acid, 3-(4-methoxyphenyl)-, 1,1-dimethylethyl ester, (2E)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-(4-methoxyphenyl)-, 1,1-dimethylethyl ester, (2E)-
• CAS No.: 53484-52-9
• Molecular Formula: C14H18O3
• Molecular Weight: 234.295
• Mol file: 53484-52-9.mol

Synonyms:2-Propenoic acid,3-(4-methoxyphenyl)-,1,1-dimethylethyl ester,(2E);tert-butyl (E)-3-(4'-methoxyphenyl)propenoate;4-methoxy-trans-cinnamic acid t-butyl ester;4-methoxy-trans-cinnamic acid tert-butyl ester;tert-butyl (E)-3-(4-methoxyphenyl)-acrylate;2-Propenoic acid,3-(4-methoxyphenyl)-,1,1-dimethylethyl ester;tert-butyl (E)-3-(4-methoxylphenyl)-2-propenoate;tert-butyl (E)-3-(4-methoxyphenyl)prop-2-enoate;

Chemical Property of 2-Propenoic acid, 3-(4-methoxyphenyl)-, 1,1-dimethylethyl ester, (2E)-

Chemical Property:

• Melting Point: 34-35 °C
• Boiling Point: 165 °C(Press: 18 Torr)
• PSA: 35.53000
• Density: 1.046±0.06 g/cm3(Predicted)
• LogP: 3.05010

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenoic acid, 3-(4-methoxyphenyl)-, 1,1-dimethylethyl ester, (2E)-

There total 41 articles about 2-Propenoic acid, 3-(4-methoxyphenyl)-, 1,1-dimethylethyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-bromo-4-methoxy-benzene (104-92-7) + tert-Butyl acrylate (1663-39-4,25232-27-3) → tert-butyl (E)-3-(4-methoxyphenyl)prop-2-enoate (53484-52-9)

Guidance literature:

With C₃₁H₃₈ClN₃Pd; potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ol8012809

Reference yield: 100.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + para-iodoanisole (696-62-8) → tert-butyl (E)-3-(4-methoxyphenyl)prop-2-enoate (53484-52-9)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; potassium carbonate; palladium diacetate; In N,N-dimethyl-formamide; at 120 ℃; for 6h;

DOI:10.1055/s-2005-869980

Reference yield: 99.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + para-iodoanisole (696-62-8) → 3-(4-methoxyphenyl)-acrylic acid tert-butyl ester (53484-52-9)

Guidance literature:

With potassium carbonate; Co_0.38Fe_0.57LaO₃Pd_0.05; In isopropyl alcohol; at 100 ℃; for 1h; Product distribution / selectivity;

upstream raw materials:

(E)-3-(4-methoxyphenyl)propenoyl chloride

potassium tert-butylate

tert-butyl bis(trimethylsilyl)acetate

4-methoxy-benzaldehyde

Downstream raw materials:

tert-butyl (3R,αS)-3-[N-benzyl-N-(α-methylbenzyl)-amino]-3-(4'-methoxyphenyl)propanoate

tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-3-(4-methoxyphenyl)propanoate

Refernces

• 1、 Pang, Haobo,Hu, Yuting,Yu, Julie,Gallou, Fabrice,Lipshutz, Bruce H.. "Water-Sculpting of a Heterogeneous Nanoparticle Precatalyst for Mizoroki-Heck Couplings under Aqueous Micellar Catalysis Conditions". supporting information. p. 3373 - 3382. Retrieved 2021/04/07.
• 2、 Thakore, Ruchita R.,Takale, Balaram S.,Hu, Yuting,Ramer, Selene,Kostal, Jakub,Gallou, Fabrice,Lipshutz, Bruce H.. "“TPG-lite”: A new, simplified “designer” surfactant for general use in synthesis under micellar catalysis conditions in recyclable water". . . Retrieved 2021/04/22.