N,N'-dibenzylpyridine-2,3-diamine

Base Information

• Chemical Name: N,N'-dibenzylpyridine-2,3-diamine
• CAS No.: 54231-39-9
• Molecular Formula: C19H19N3
• Molecular Weight: 289.38
• DSSTox Substance ID: DTXSID001264308
• Nikkaji Number: J652.410I
• Mol file: 54231-39-9.mol

Synonyms:N,N'-dibenzylpyridine-2,3-diamine;2,3-dibenzylaminopyridine;DTXSID001264308;54231-39-9;N2,N3-Bis(phenylmethyl)-2,3-pyridinediamine

Chemical Property of N,N'-dibenzylpyridine-2,3-diamine

Chemical Property:

• XLogP3: 4.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 289.157897619
• Heavy Atom Count: 22
• Complexity: 295

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CNC2=C(N=CC=C2)NCC3=CC=CC=C3

Technology Process of N,N'-dibenzylpyridine-2,3-diamine

There total 3 articles about N,N'-dibenzylpyridine-2,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2,3-Diaminopyridine (452-58-4) + benzaldehyde (100-52-7) → N,N'-Bis(phenylmethyl)-2,3-pyridinediamine (54231-39-9)

Guidance literature:

2,3-Diaminopyridine; benzaldehyde; In benzene; at 20 ℃; for 23h; Molecular sieve; Reflux;

With sodium tetrahydroborate; In ethanol; for 18h; Reflux;

DOI:10.1021/acs.joc.9b02714

Reference yield:

2,3-Diaminopyridine (452-58-4) + benzaldehyde (100-52-7) → N,N'-Bis(phenylmethyl)-2,3-pyridinediamine (54231-39-9) + 2-amino-3-<(phenylmethyl)amino>pyridine (79707-12-3) + N2-benzyl-2,3-pyridinediamine (32282-07-8)

Guidance literature:

With sodium tetrahydroborate; 4 A molecular sieve; Yield given. Multistep reaction. Yields of byproduct given; 1.) C₆H₆, reflux, 3 h; r.t., 20 h, 2.) EtOH, reflux, 18 h;

DOI:10.1021/jo00109a029

Reference yield:

→ N,N'-Bis(phenylmethyl)-2,3-pyridinediamine (54231-39-9)

Guidance literature:

2-Nitro-3-chloropyridin IIa, Benzylamin;

DOI:10.1007/BF00480925

upstream raw materials:

2,3-Diaminopyridine

benzaldehyde

Refernces

• 1、 Khanna,Weier,Lentz,Swenton,Lankin. "Facile, regioselective syntheses of N-alkylated 2,3-diaminopyridines and imidazo[4,5-b]pyridines". . p. 960 - 965. Retrieved 2007/10/02.