2,3-Diaminopyridine

Base Information

• Chemical Name: 2,3-Diaminopyridine
• CAS No.: 452-58-4
• Molecular Formula: C5H7N3
• Molecular Weight: 109.131
• Hs Code.: 29333999
• European Community (EC) Number: 207-200-9
• NSC Number: 45406
• UNII: CBX394737H
• DSSTox Substance ID: DTXSID0051493
• Nikkaji Number: J79.620D
• Wikidata: Q27275394
• Mol file: 452-58-4.mol

Synonyms:2,3-diaminopyridine

Chemical Property of 2,3-Diaminopyridine

Chemical Property:

• Appearance/Colour: brown power
• Vapor Pressure: 0.00057mmHg at 25°C
• Melting Point: 110-115 °C(lit.)
• Refractive Index: 1.5340 (estimate)
• Boiling Point: 311.3 °C at 760 mmHg
• PKA: 6.78±0.36(Predicted)
• Flash Point: 167.7 °C
• PSA: 64.93000
• Density: 1.251 g/cm³
• LogP: 1.40840
• Storage Temp.: Refrigerator (+4°C)
• Sensitive.: Air Sensitive
• Solubility.: H2O: soluble50mg/mL, opaque (brown to very dark brown)
• Water Solubility.: 100 g/L (20 ºC)
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 109.063997236
• Heavy Atom Count: 8
• Complexity: 74.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3-Diaminopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi, T
• Hazard Codes: Xn,Xi,T
• Statements: 22-36/37/38-25
• Safety Statements: 26-36/37-45-37/39-28A-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)N)N
• Uses: 2,3-Diaminopyridine was used in the synthesis of 2,3-diaminopyridinium-4-hydroxybenzoate1. It was used as internal standard in analysis of poly(amidoamine)dendrimers having different terminal functionalities by capillary electrophoresis. It was used as reagent in synthesis of imidazopyridines and organometallic complexes.

Technology Process of 2,3-Diaminopyridine

There total 28 articles about 2,3-Diaminopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3,3'-dinitro-2,2'-hydrazobipyridine (101458-28-0) → 2,3-Diaminopyridine (452-58-4)

Guidance literature:

With hydrogen; nickel; In ethanol; for 3h; under 3102.9 Torr; Ambient temperature;

DOI:10.1002/jhet.5570230306

Reference yield: 89.0%

2-amino-3-nitropyridine (4214-75-9) → 2,3-Diaminopyridine (452-58-4)

Guidance literature:

With sulfur; sodium hydroxide; In methanol; water; at 80 ℃; for 16h; Green chemistry;

DOI:10.1002/ejoc.202000064

Reference yield: 70.0%

2-Hydrazino-3-nitropyridine (15367-16-5) → 2,3-Diaminopyridine (452-58-4)

Guidance literature:

With hydrogen; nickel; In tetrahydrofuran; ethanol; at 65 ℃; for 16h; under 3102.9 Torr;

DOI:10.1002/jhet.5570230306

upstream raw materials:

pyridin-3-ylamine

2-chloro-3-aminopyridine

5-bromo-pyridine-2,3-diamine

3-amino-2-nitropyridine

Downstream raw materials:

2-benzyl-3H-imidazo<4,5-b>pyridine

N,N'-Bis(phenylmethyl)-2,3-pyridinediamine

2-amino-3-<(phenylmethyl)amino>pyridine

N²-benzyl-2,3-pyridinediamine

Refernces

• 1、 -. "Synthesis method of aminopyridine compounds". Paragraph 0053-0054. . Retrieved 2020/10/14.
• 2、 -. "Benzimidazole derivatives, their preparation and their application in medicine and pharmacology (by machine translation)". Paragraph 0136-0137. . Retrieved 2019/07/16.