5-Bromopyridine-2,3-diamine

Base Information

• Chemical Name: 5-Bromopyridine-2,3-diamine
• CAS No.: 38875-53-5
• Molecular Formula: C5H6BrN3
• Molecular Weight: 188.027
• Hs Code.: 29333990
• European Community (EC) Number: 254-172-9
• UNII: VS8NFO6O1G
• DSSTox Substance ID: DTXSID30192129
• Nikkaji Number: J319.857J
• Wikidata: Q72462723
• ChEMBL ID: CHEMBL4060760
• Mol file: 38875-53-5.mol

Synonyms:2,3-Diamino-5-bromopyridine;38875-53-5;5-Bromopyridine-2,3-diamine;5-Bromo-2,3-diaminopyridine;2,3-Pyridinediamine, 5-bromo-;5-bromo-2,3-pyridinediamine;VS8NFO6O1G;EINECS 254-172-9;MFCD00460094;UNII-VS8NFO6O1G;5-Bromopyridin-2,3-diamine;SCHEMBL189764;C5-H6-Br-N3;5-bromo pyridine-2,3-diamine;5-bromo-2,3- diaminopyridine;5-Bromo-pyridine-2,3-diamine;CHEMBL4060760;DTXSID30192129;HMS1768B21;BCP21826;STR08529;BBL013028;CL0001;STK696227;2,3-Diamino-5-bromopyridine, 97%;AKOS000267995;AC-3571;CS-W002619;FG-0469;PB10156;SB11854;BP-12098;A6549;AM20061863;FT-0620069;EN300-07258;AH-357/03488033;W-106462;Z56950512;5-Bromopyridine-2,3-diamine pound>>5-Bromo-2,3-diaminopyridine;BR9

Chemical Property of 5-Bromopyridine-2,3-diamine

Chemical Property:

• Appearance/Colour: light yellow to purple or light brown powder
• Vapor Pressure: 0.000308mmHg at 25°C
• Melting Point: 155 °C (dec.)(lit.)
• Refractive Index: 1.6400 (estimate)
• Boiling Point: 320.9 °C at 760 mmHg
• PKA: 4.53±0.49(Predicted)
• Flash Point: 147.9 °C
• PSA: 64.93000
• Density: 1.818 g/cm³
• LogP: 2.17090
• Storage Temp.: Room temperature.
• Solubility.: soluble in Methanol
• Water Solubility.: soluble in hot water
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 186.97451
• Heavy Atom Count: 9
• Complexity: 98.2

Purity/Quality:

99% ^*data from raw suppliers

2,3-Diamino-5-bromopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi; C
• Hazard Codes: Xi,C
• Statements: 36/37/38-34
• Safety Statements: 26-36-37/39-45-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1N)N)Br
• Uses: 2,3-Diamino-5-bromopyridine may be used in the preparation of the following heterocyclic compounds:6-bromoimidazo-[b]pyridine11-bromopyrido[2′,3′:5,6]pyrazino[2,3-f][1,10]phenanthroline6-bromo-3-(tetrahydro-2H-pyran-2-yl)-3H-imidazo[4,5-b]pyridine

Technology Process of 5-Bromopyridine-2,3-diamine

There total 7 articles about 5-Bromopyridine-2,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-bromo-3-nitro-pyridin-2-ylamine (6945-68-2) → 5-bromo-pyridine-2,3-diamine (38875-53-5)

Guidance literature:

With hydrazine hydrate; Ru-carbon; In ethanol; for 3h; Heating;

DOI:10.1021/jm00018a012

Reference yield: 98.0%

SnCl2 hydrate + 5-bromo-3-nitro-pyridin-2-ylamine (6945-68-2) → 5-bromo-pyridine-2,3-diamine (38875-53-5)

Guidance literature:

In sodium hydroxide; ethanol;

Reference yield: 93.0%

5-bromo-3-nitro-pyridin-2-ylamine (6945-68-2) + pyrographite (7440-44-0) → 5-bromo-pyridine-2,3-diamine (38875-53-5)

Guidance literature:

With hydrazine; In methanol; ethyl acetate;

upstream raw materials:

5-bromo-3-nitro-pyridin-2-ylamine

pyrographite

6-amino-5-nitronicotinonitrile

Downstream raw materials:

6-bromo-1H-imidazo[4,5-b]pyridine

6-bromo-1H-imidazo[4,5-b]pyridine-2(3H)-thione

6-bromo-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

2,3-Diaminopyridine

Refernces

• 1、 Starosotnikov, Alexey M.,Ilkov, Kirill V.,Bastrakov, Maxim A.,Fedyanin, Ivan V.,Kokorekin, Vladimir A.. "Mild and efficient addition of carbon nucleophiles to condensed pyridines: influence of structure and limits of applicability". . p. 92 - 100. Retrieved 2020/02/28.
• 2、 Murugesan, Kathiravan,Senthamarai, Thirusangumurugan,Sohail, Manzar,Alshammari, Ahmad S.,Pohl, Marga-Martina,Beller, Matthias,Jagadeesh, Rajenahally V.. "Cobalt-based nanoparticles prepared from MOF-carbon templates as efficient hydrogenation catalysts". . p. 8553 - 8560. Retrieved 2018/11/30.