naphtho[2,1-b]furan-2-carboxylic acid(SALTDATA: FREE)

Base Information

• Chemical Name: naphtho[2,1-b]furan-2-carboxylic acid(SALTDATA: FREE)
• CAS No.: 5656-67-7
• Molecular Formula: C13H8O3
• Molecular Weight: 212.205
• Hs Code.: 2932990090
• Mol file: 5656-67-7.mol

Synonyms:

Chemical Property of naphtho[2,1-b]furan-2-carboxylic acid(SALTDATA: FREE)

Chemical Property:

• PSA: 50.44000
• LogP: 3.28420

Purity/Quality:

97% ^*data from raw suppliers

naphtho[2,1-b]furan-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of naphtho[2,1-b]furan-2-carboxylic acid(SALTDATA: FREE)

There total 11 articles about naphtho[2,1-b]furan-2-carboxylic acid(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl bromoacetate (105-36-2) + 2-hydroxynaphthalene-1-carbaldehyde (708-06-5) → acide naphtho<2,1-b>furanne carboxilique (5656-67-7) + 2-carbetossinafto<2,1-b>furano (32730-03-3)

Guidance literature:

2-hydroxynaphthalene-1-carbaldehyde; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

ethyl bromoacetate; In N,N-dimethyl-formamide; at 140 ℃; for 22h;

Reference yield: 84.0%

2-(β,β-dibromovinyl)-2-naphthol (947232-06-6) + molybdenum hexacarbonyl (13939-06-5,199620-15-0) → acide naphtho<2,1-b>furanne carboxilique (5656-67-7)

Guidance literature:

With [2,2]bipyridinyl; water; triethylamine; copper(ll) bromide; In tert-butyl alcohol; at 90 ℃; for 8h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.0c01620

Reference yield: 81.0%

bromoacetic acid tert-butyl ester (5292-43-3) + 2-hydroxynaphthalene-1-carbaldehyde (708-06-5) → acide naphtho<2,1-b>furanne carboxilique (5656-67-7)

Guidance literature:

bromoacetic acid tert-butyl ester; 2-hydroxynaphthalene-1-carbaldehyde; With potassium carbonate; In N,N-dimethyl acetamide; at 80 - 120 ℃; for 2h;

With hydrogen bromide; acetic acid; In water; at 40 ℃; for 1h;

upstream raw materials:

(1-formyl-naphthalen-2-yloxy)acetic acid ethyl ester

Diethyl 2-bromomalonate

2-hydroxynaphthalene-1-carbaldehyde

3H-benzo[f]chromen-3-one

Downstream raw materials:

naphtho[2,1-b]furan

naphtho[2,1-b]furan-2-carboxyhydrazide

STK899704

2-carbetossinafto<2,1-b>furano

Refernces

• 1、 Mo, Qinliang,Sun, Nan,Jin, Liqun,Hu, Baoxiang,Shen, Zhenlu,Hu, Xinquan. "Tandem Synthesis of 2-Carboxybenzofurans via Sequential Cu-Catalyzed C-O Coupling and Mo(CO)6-Mediated Carbonylation Reactions". . p. 11490 - 11500. Retrieved 2020/10/12.
• 2、 -. "Compound, a manufacturing method of an optical film, and optical film". Paragraph 0240; 0241; 0242. . Retrieved 2020/04/17.