7-Hydroxyquinoline

Base Information

• Chemical Name: 7-Hydroxyquinoline
• CAS No.: 580-20-1
• Molecular Formula: C9H7NO
• Molecular Weight: 145.161
• Hs Code.: 29334900
• Mol file: 580-20-1.mol

Synonyms:NSC 87630;Quinolin-7-ol;

Chemical Property of 7-Hydroxyquinoline

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 1.7E-07mmHg at 25°C
• Melting Point: 239-244 °C
• Refractive Index: 1.642
• Boiling Point: 312.954 °C at 760 mmHg
• PKA: pK1:5.48(＋1);pK2:8.85(0) (20°C)
• Flash Point: 143.07 °C
• PSA: 33.12000
• Density: 1.26 g/cm³
• LogP: 1.94040
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: 454.3mg/L(20 oC)

Purity/Quality:

99% ^*data from raw suppliers

7-Hydroxyquinoline- ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/21/22-22
• Safety Statements: 36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Hydroxyquinoline

There total 25 articles about 7-Hydroxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

7-hydroxy-1,2,3,4-tetrahydroquinoline (58196-33-1) → quinolin-7-ol (580-20-1)

Guidance literature:

With hexagonal boron carbon nitride; In water; at 25 ℃; for 12h; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1002/anie.201800319

Reference yield: 78.0%

7-bromoquinoline (4965-36-0) → quinolin-7-ol (580-20-1)

Guidance literature:

With copper(I) oxide; 1D-1-O-Methyl-muco-inostol; sodium hydroxide; In water; at 130 ℃; for 6h;

Reference yield: 25.0%

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) + m-Hydroxyaniline (591-27-5) → quinolin-7-ol (580-20-1)

Guidance literature:

With sulfuric acid; In water; at 36 - 200 ℃; for 0.25h; Microwave irradiation; Sealed tube; Green chemistry;

DOI:10.1039/c4ra00758a

upstream raw materials:

quinolin-7-ylamine

7-methoxyquinoline

meta-nitrophenol

glycerol

Downstream raw materials:

[2-(4-Methoxy-phenyl)-ethyl]-carbamic acid quinolin-7-yl ester

(2-Chloro-phenyl)-carbamic acid quinolin-7-yl ester

(2-Methoxy-phenyl)-carbamic acid quinolin-7-yl ester

(4-Methoxy-phenyl)-carbamic acid quinolin-7-yl ester

Refernces

• 1、 Muguruma, Kyohei,Pradipta, Ambara R.,Ode, Yudai,Terashima, Kazuki,Michiba, Hiroyuki,Fujii, Motoko,Tanaka, Katsunori. "Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry". . . Retrieved 2020.
• 2、 Bahnemann, Detlef W.,Balayeva, Narmina O.,Dillert, Ralf,Mamiyev, Zamin,Zheng, Nan. "Rh/TiO2-Photocatalyzed Acceptorless Dehydrogenation of N-Heterocycles upon Visible-Light Illumination". . p. 5542 - 5553. Retrieved 2020/08/25.