7-Methoxyquinoline

Base Information

• Chemical Name: 7-Methoxyquinoline
• CAS No.: 4964-76-5
• Molecular Formula: C10H9NO
• Molecular Weight: 159.188
• Hs Code.: 2933499090
• European Community (EC) Number: 838-295-0
• DSSTox Substance ID: DTXSID20197946
• Nikkaji Number: J112.928G
• Wikidata: Q72485988
• Mol file: 4964-76-5.mol

Synonyms:7-methoxyquinoline

Chemical Property of 7-Methoxyquinoline

Chemical Property:

• Vapor Pressure: 0.00656mmHg at 25°C
• Refractive Index: 1.61
• Boiling Point: 280.1 °C at 760 mmHg
• Flash Point: 102.7 °C
• PSA: 22.12000
• Density: 1.13 g/cm³
• LogP: 2.24340
• Storage Temp.: Refrigerator
• Solubility.: Chloroform
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 159.068413911
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

99% ^*data from raw suppliers

7-Methoxyquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC2=C(C=CC=N2)C=C1
• Uses: 7-Methoxyquinoline (cas# 4964-76-5) is a compound useful in organic synthesis.

Technology Process of 7-Methoxyquinoline

There total 16 articles about 7-Methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl iodide (74-88-4) → 7-methoxyquinoline (4964-76-5)

Guidance literature:

quinolin-7-ol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield: 89.0%

7-methoxy-1,2,3,4-tetrahydroquinoline (19500-61-9) → 7-methoxyquinoline (4964-76-5)

Guidance literature:

With potassium carbonate; In ethanol; at 20 ℃; for 24h; Irradiation;

Reference yield: 85.0%

7-methoxy-2-(methylthio)quinoline (682350-96-5) → 7-methoxyquinoline (4964-76-5)

Guidance literature:

With nickel; In ethanol; Heating;

DOI:10.1055/s-2004-815400

upstream raw materials:

7-bromoquinoline

m-Anisidine

glycerol

5-p-methoxyphenyl-1-methyl-2-aza-1-oxapentadiene

Downstream raw materials:

quinolin-7-ol

N-methylquinolin-7-amine

7-methoxy-1,2,3,4-tetrahydroquinoline

8-amino-7-methoxyquinoline

Refernces

• 1、 Liu, Yanpeng,Yu, Tianjun,Zeng, Yi,Chen, Jinping,Yang, Guoqiang,Li, Yi. "Efficient acceptorless dehydrogenation of hydrogen-rich N-heterocycles photocatalyzed by Ni(OH)2@CdSe/CdS quantum dots". . p. 3810 - 3817. Retrieved 2021/06/18.
• 2、 Zheng, Meifang,Shi, Jiale,Yuan, Tao,Wang, Xinchen. "Metal-Free Dehydrogenation of N-Heterocycles by Ternary h-BCN Nanosheets with Visible Light". supporting information. p. 5487 - 5491. Retrieved 2018/04/02.