7-Methoxy-1,2,3,4-tetrahydroquinoline

Base Information

• Chemical Name: 7-Methoxy-1,2,3,4-tetrahydroquinoline
• CAS No.: 19500-61-9
• Molecular Formula: C10H13NO
• Molecular Weight: 163.219
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID90585674
• Nikkaji Number: J1.692.941G
• Wikidata: Q82477673
• Mol file: 19500-61-9.mol

Synonyms:7-Methoxy-1,2,3,4-tetrahydroquinoline;19500-61-9;MFCD08544271;7-Methoxy-1,2,3,4-tetrahydro-quinoline;Quinoline, 1,2,3,4-tetrahydro-7-methoxy-;7-methoxy-tetrahydroquinoline;SCHEMBL1395133;AMY8960;DTXSID90585674;WDKNRIQDGSVRBO-UHFFFAOYSA-N;AKOS022175230;MB06336;AS-20049;SY212096;CS-0135131;A18389;EN300-269394;N13147;7-METHOXY-1,2,3,4-TETRA HYDROQUINOLINE;7-methoxy-1,2,3,4-tetrahydroquinoline;7-Methoxy-1,2,3,4-tetrahydroquinoline hydrochloride

Chemical Property of 7-Methoxy-1,2,3,4-tetrahydroquinoline

Chemical Property:

• PSA: 21.26000
• LogP: 2.19130
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 163.099714038
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

95% purity ^*data from raw suppliers

7-Methoxy-1,2,3,4-tetrahydroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(CCCN2)C=C1

Technology Process of 7-Methoxy-1,2,3,4-tetrahydroquinoline

There total 14 articles about 7-Methoxy-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

7-methoxy-2-oxo-1,2,3,4-tetrahydroquinoline (22246-17-9) → 7-methoxy-1,2,3,4-tetrahydroquinoline (19500-61-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 13h;

DOI:10.1002/anie.201402750

Reference yield: 92.0%

7-methoxy-3,4-dihydro-2H-quinoline-1-carboxylic acid tert-butyl ester (1023913-73-6) → 7-methoxy-1,2,3,4-tetrahydroquinoline (19500-61-9)

Guidance literature:

7-methoxy-3,4-dihydro-2H-quinoline-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 24h;

With sodium carbonate; In dichloromethane; water; pH=9;

Reference yield: 90.0%

7-methoxyquinoline (4964-76-5) → 7-methoxy-1,2,3,4-tetrahydroquinoline (19500-61-9)

Guidance literature:

With dichloro(μ-chloro)(μ-hydrido)bis(η-p-cymene)diruthenium(II); hydrogen; In neat (no solvent); at 75 ℃; for 24h; under 22502.3 Torr;

DOI:10.1039/d0cy00928h

upstream raw materials:

7-methoxyquinoline

hydrogenchloride

6-methoxyindan-1-one oxime

7-methoxy-3,4-dihydro-2H-quinoline-1-carboxylic acid tert-butyl ester

Downstream raw materials:

1-benzoyl-7-methoxy-1,2,3,4-tetrahydro-quinoline

7-hydroxy-1,2,3,4-tetrahydroquinoline

3-(7-methoxy-6-(4-nitrophenylazo)-3,4-dihydro-2H-quinolin-1-yl)propane-1-sulfonic acid

3-(7-methoxy-6-(4-nitrophenylazo)-3,4-dihydro-2H-quinolin-1-yl)propane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

Refernces

• 1、 Xia, Yuehan,Yu, Mingcheng,Zhao, Yunpeng,Xia, Li,Huang, Yafei,Sun, Nannan,Song, Meiqi,Guo, Huimin,Zhang, Yunyi,Zhu, Di,Xie, Qiong,Wang, Yonghui. "Discovery of tetrahydroquinolines and benzomorpholines as novel potent RORγt agonists". . . Retrieved 2020/12/04.
• 2、 Catalano, Marco,Moroglu, Mustafa,Balbi, Petra,Mazzieri, Federica,Clayton, James,Andrews, Katrina H.,Bigatti, Martina,Scheuermann, J?rg,Conway, Stuart J.,Neri, Dario. "Selective Fragments for the CREBBP Bromodomain Identified from an Encoded Self-assembly Chemical Library". supporting information. p. 1752 - 1756. Retrieved 2020/08/21.