BAPTA TETRAETHYL ESTER

Base Information

• Chemical Name: BAPTA TETRAETHYL ESTER
• CAS No.: 73630-07-6
• Molecular Formula: C30H40N2O10
• Molecular Weight: 588.655
• Mol file: 73630-07-6.mol

Synonyms:ethyl 2-[2-[2-[2-[bis(2-ethoxy-2-oxoethyl)amino]phenoxy]ethoxy]-N-(2-ethoxy-2-oxoethyl)anilino]acetate;

Chemical Property of BAPTA TETRAETHYL ESTER

Chemical Property:

• Vapor Pressure: 3.69E-17mmHg at 25°C
• Melting Point: 98-100oC
• Boiling Point: 657.4°Cat760mmHg
• Flash Point: 351.4°C
• PSA: 130.14000
• Density: 1.21g/cm³
• LogP: 3.00960
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-[2-[2-[2-[bis(2-Ethoxy-2-oxoethyl)amino]phenoxy]ethoxy]-N-(2-ethoxy-2-oxoethyl)anilino]acetate ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 22-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BAPTA TETRAETHYL ESTER

There total 5 articles about BAPTA TETRAETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1,2-Bis(2-aminophenoxy)ethane (52411-34-4) + ethyl bromoacetate (105-36-2) → 1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid tetraethyl ester (73630-07-6)

Guidance literature:

With disodium hydrogenphosphate; potassium iodide; In acetonitrile; at 90 ℃; for 72h;

DOI:10.1002/ejoc.202100948

Reference yield:

1,2-bis(2-nitrophenoxy)ethane (51661-19-9) → 1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid tetraethyl ester (73630-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol

2: i-Pr₂NEt / dimethylformamide

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jf0201780

Reference yield:

sodium o-nitrophenate (824-39-5) → 1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid tetraethyl ester (73630-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylformamide

2: H₂ / Pd/C / ethanol

3: i-Pr₂NEt / dimethylformamide

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jf0201780

upstream raw materials:

1,2-Bis(2-aminophenoxy)ethane

ethyl bromoacetate

1,2-bis(2-nitrophenoxy)ethane

sodium o-nitrophenate

Downstream raw materials:

C₃₀H₃₈Br₂N₂O₁₀

C₄₀H₃₈N₄O₁₂

1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid tetraethyl ester

C₄₈H₅₄N₄O₁₂

Refernces

• 1、 Liu, Yuandong,Liu, Zhichao,Zhao, Fan,Tian, Yang. "Long-Term Tracking and Dynamically Quantifying of Reversible Changes of Extracellular Ca2+ in Multiple Brain Regions of Freely Moving Animals". supporting information. p. 14429 - 14437. Retrieved 2021/05/03.
• 2、 Bhattacharyya, Koyel X.,Boubekeur-Lecaque, Le?la,Tapsoba, Issa,Maisonhaute, Emmanuel,Sch?llhorn, Bernd,Amatore, Christian. "Water-soluble, redox-active organometallic calcium chelators". supporting information. p. 14257 - 14264. Retrieved 2013/04/10.