N-Methyl-1-amino-hex-5-ene

Base Information

• Chemical Name: N-Methyl-1-amino-hex-5-ene
• CAS No.: 55863-02-0
• Molecular Formula: C7H15N
• Molecular Weight: 113.203
• Hs Code.: 2921199090
• Mol file: 55863-02-0.mol

Synonyms:N-Methyl-1-amino-hex-5-ene;N-hex-5-enyl-N-methylamine;(hex-5-enyl)(methyl)amine;N-methyl hex-5-en-1-amine;5-hexen-1-amine,n-methyl;N-methylhex-5-enamine;N-methyl-N-hex-5-enylamine;HEX017;N-methyl-N-hex-5-enylamin;N-METHYL-5-HEXEN-1-AMINE;

Chemical Property of N-Methyl-1-amino-hex-5-ene

Chemical Property:

• Boiling Point: 146.5±19.0 °C(Predicted)
• PKA: 10.74±0.10(Predicted)
• PSA: 12.03000
• Density: 0.764±0.06 g/cm3(Predicted)
• LogP: 1.95300
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

N-Methylhex-5-en-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Methylhex-5-en-1-amine can be used as a reagent to prepare quinazoline substituted cyclopentane and proline-urea based macrocycles as Hepatitis C virus (HCV) NS3/4A protease inhibitors.

Technology Process of N-Methyl-1-amino-hex-5-ene

There total 8 articles about N-Methyl-1-amino-hex-5-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

6-Bromo-1-hexene (2695-47-8) + methylamine (74-89-5) → N-methylhex-5-en-1-amine (55863-02-0)

Guidance literature:

In methanol; at 40 ℃; for 3h; Solvent; Temperature;

Reference yield: 34.0%

2,2,2-trifluoro-N-(hex-5-enyl)-N-methylacetamide (922520-05-6) → N-methylhex-5-en-1-amine (55863-02-0)

Guidance literature:

With methanol; potassium hydroxide; water; at 20 ℃; for 12h;

Reference yield:

N-Hex-5-enyl-formamide → N-methylhex-5-en-1-amine (55863-02-0)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 35 ℃;

DOI:10.1002/anie.200460880

upstream raw materials:

N-Methyl-6-hydroxyhexylamine

6-Bromo-1-hexene

methylamine

methylamine hydrochloride

Downstream raw materials:

1,2-dimethylpiperidine

(1R,2S)-ethyl 1-((1R,2R,4R)-2-(hex-5-enyl(methyl)carbamoyl)-4-(7-methoxy-2-phenylquinazolin-4-yloxy)cyclopentanecarboxamido)-2-vinylcyclopropanecarboxylate

C₃₇H₄₃FN₄O₆

(1R,2S)-1-((1R,2R,4R)-2-(hex-5-enyl(methyl)carbamoyl)-4-(7-methoxy-8-methyl-2-phenylquinazolin-4-yloxy)cyclopentanecarboxamido)-2-vinylcyclopropanecarboxylic acid ethyl ester

Refernces

• 1、 -. "Synthesizing process of N-methyl-5-hexene-1-amine". Paragraph 0014-0028. . Retrieved 2018/06/16.
• 2、 -. "POLYMORPHIC FORMS OF A MACROCYCLIC INHIBITOR OF HCV". Page/Page column 30. . Retrieved 2008/12/07.