Benzeneacetic acid, a-methyl-4-(methyl-2-thiazolylamino)-

Base Information

• Chemical Name: Benzeneacetic acid, a-methyl-4-(methyl-2-thiazolylamino)-
• CAS No.: 56355-31-8
• Molecular Formula: C₁₃H₁₄N₂O₂S
• Molecular Weight: 262.332
• Mol file: 56355-31-8.mol

Synonyms:

Chemical Property of Benzeneacetic acid, a-methyl-4-(methyl-2-thiazolylamino)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, a-methyl-4-(methyl-2-thiazolylamino)-

There total 11 articles about Benzeneacetic acid, a-methyl-4-(methyl-2-thiazolylamino)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-ethyl cyano(2-nitrophenyl)acetate (65548-02-9) → 2-[4-(methyl-thiazol-2-yl-amino)-phenyl]-propionic acid (56355-31-8)

Guidance literature:

Multi-step reaction with 9 steps

1: 63.4 percent / K₂CO₃ / acetone / 5 h / Heating

2: 82.9 percent / K₂CO₃ / aq. ethanol / 18 h / Heating

3: 89.8 percent / H₂ / 5percent Pd-C / ethanol

4: 99.3 percent / CH₂Cl₂ / 1 h / Ambient temperature

5: 11.0 g / Na₂CO₃ / dimethylformamide / 2.5 h / Ambient temperature

6: 4.8percent aq. NaOH / benzene; dimethylformamide; H₂O / 1 h / 8 °C

7: 70 percent / NH₄SCN / acetone / 1 h / Ambient temperature

8: K₂CO₃ / methanol; H₂O / 9 h / Heating

9: 20percent HCl / aq. propan-2-ol / 6 h / 90 - 95 °C

With hydrogenchloride; sodium hydroxide; hydrogen; ammonium thiocyanate; sodium carbonate; potassium carbonate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; benzene;

DOI:10.1248/cpb.31.3424

Reference yield:

2-Chloronitrobenzene (88-73-3) → 2-[4-(methyl-thiazol-2-yl-amino)-phenyl]-propionic acid (56355-31-8)

Guidance literature:

Multi-step reaction with 10 steps

1: 98.6 g / NaH / dimethylformamide / 24 h / 44 - 47 °C

2: 63.4 percent / K₂CO₃ / acetone / 5 h / Heating

3: 82.9 percent / K₂CO₃ / aq. ethanol / 18 h / Heating

4: 89.8 percent / H₂ / 5percent Pd-C / ethanol

5: 99.3 percent / CH₂Cl₂ / 1 h / Ambient temperature

6: 11.0 g / Na₂CO₃ / dimethylformamide / 2.5 h / Ambient temperature

7: 4.8percent aq. NaOH / benzene; dimethylformamide; H₂O / 1 h / 8 °C

8: 70 percent / NH₄SCN / acetone / 1 h / Ambient temperature

9: K₂CO₃ / methanol; H₂O / 9 h / Heating

10: 20percent HCl / aq. propan-2-ol / 6 h / 90 - 95 °C

With hydrogenchloride; sodium hydroxide; hydrogen; ammonium thiocyanate; sodium hydride; sodium carbonate; potassium carbonate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; benzene;

DOI:10.1248/cpb.31.3424

Reference yield:

2-(2-nitrophenyl)propanenitrile (65783-00-8) → 2-[4-(methyl-thiazol-2-yl-amino)-phenyl]-propionic acid (56355-31-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 89.8 percent / H₂ / 5percent Pd-C / ethanol

2: 99.3 percent / CH₂Cl₂ / 1 h / Ambient temperature

3: 11.0 g / Na₂CO₃ / dimethylformamide / 2.5 h / Ambient temperature

4: 4.8percent aq. NaOH / benzene; dimethylformamide; H₂O / 1 h / 8 °C

5: 70 percent / NH₄SCN / acetone / 1 h / Ambient temperature

6: K₂CO₃ / methanol; H₂O / 9 h / Heating

7: 20percent HCl / aq. propan-2-ol / 6 h / 90 - 95 °C

With hydrogenchloride; sodium hydroxide; hydrogen; ammonium thiocyanate; sodium carbonate; potassium carbonate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; benzene;

DOI:10.1248/cpb.31.3424

upstream raw materials:

chloroacetaldehyde diethyl acetal

(+/-)-ethyl cyano(2-nitrophenyl)acetate

2-Chloronitrobenzene

2-(2-aminophenyl)propionitrile

Refernces

• 1、 -. "Thiazole derivatives of benzoic and phenylalkanoic acids". . . Retrieved 2008/06/13.