9-ethyl-9H-carbazole-3-carboxylic acid

Base Information

• Chemical Name: 9-ethyl-9H-carbazole-3-carboxylic acid
• CAS No.: 57102-98-4
• Molecular Formula: C15H13NO2
• Molecular Weight: 239.274
• DSSTox Substance ID: DTXSID901284145
• Mol file: 57102-98-4.mol

Synonyms:9-ethyl-9H-carbazole-3-carboxylic acid;57102-98-4;9-ethylcarbazole-3-carboxylic acid;9-ethyl-9 h-carbazole-3-carboxylic acid;3-Carboxy-9-ethylcarbazole;SCHEMBL2734561;DTXSID901284145;N-ethylcarbazole-3-carboxylic acid;9-ethyl-carbazole-3-carboxylic acid;MFCD06203133;AKOS000265490;9-ethyl-9H-carbazole-3-carboxylicacid;AM806989;AS-63682;9H-Carbazole-3-carboxylic acid, 9-ethyl-;BB 0240556;CS-0061524;FT-0709091;W17263;A918357

Chemical Property of 9-ethyl-9H-carbazole-3-carboxylic acid

Chemical Property:

• Melting Point: 230-231°C
• PSA: 42.23000
• LogP: 3.51260
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 239.094628657
• Heavy Atom Count: 18
• Complexity: 331

Purity/Quality:

98%min ^*data from raw suppliers

9-Ethyl-9H-carbazole-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1C2=C(C=C(C=C2)C(=O)O)C3=CC=CC=C31
• Uses: 9-Ethyl-9H-carbazole-3-carboxylic Acid is a useful reagent for the preparation of an oxime ester photoinitiator.

Technology Process of 9-ethyl-9H-carbazole-3-carboxylic acid

There total 18 articles about 9-ethyl-9H-carbazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-ethyl-3-carbazolealdehyde (7570-45-8) → 9-Ethyl-9H-carbazole-3-carboxylic acid (57102-98-4)

Guidance literature:

With potassium permanganate; In water; acetone; at 20 ℃; for 5h;

DOI:10.1002/anie.201510503

Reference yield: 80.0%

9-ethyl-9H-carbazole-3-carbonitrile (57103-00-1) → 9-Ethyl-9H-carbazole-3-carboxylic acid (57102-98-4)

Guidance literature:

With potassium hydroxide; In water; for 1h; Reflux;

DOI:10.1021/acs.joc.8b02821

Reference yield:

N-ethylcarbazole-3-methyl formate (773873-63-5) → 9-Ethyl-9H-carbazole-3-carboxylic acid (57102-98-4)

Guidance literature:

In ethanol; water; at 90 ℃; Alkaline conditions;

DOI:10.1016/j.ejmech.2018.02.050

upstream raw materials:

3-iodo-9-ethylcarbazole

3-bromo-9-ethyl-9H-carbazole

diethyl sulfate

9H-carbazole-3-carboxylic acid ethyl ester

Downstream raw materials:

N-ethyl-3-(ω-aminopentylaminocarbonyl)-carbazole

9-ethyl-9H-carbazole-3-carboxylic acid phenylethylamide

Refernces

• 1、 Chauhan, Alex,Jain, Neeraj,Pandey, Nilesh,Parikh, Paranjay,Patel, Kaushal,Patel, Mrugesh,Timaniya, Jignesh. "Coumarin-carbazole based functionalized pyrazolines: Synthesis, characterization, anticancer investigation and molecular docking". . p. 27627 - 27644. Retrieved 2021/08/25.
• 2、 -. "NOVEL CARBAZOLE EHOP-016 DERIVATIVES AS ANTI-CANCER AND ANTI-MIGRATORY AGENTS". Paragraph 0187; 0188. . Retrieved 2019/05/15.