2-ISO-PROPOXYBENZALDEHYDE

Base Information

• Chemical Name: 2-ISO-PROPOXYBENZALDEHYDE
• CAS No.: 22921-58-0
• Molecular Formula: C10H12O2
• Molecular Weight: 164.204
• Hs Code.: 2912499000
• Mol file: 22921-58-0.mol

Synonyms:2-(Methylethoxy)benzaldehyde;

Chemical Property of 2-ISO-PROPOXYBENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.0146mmHg at 25°C
• Refractive Index: 1.529
• Boiling Point: 257.3 °C at 760 mmHg
• Flash Point: 107.9 °C
• PSA: 26.30000
• Density: 1.036 g/cm³
• LogP: 2.28630
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2-Isopropoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Isopropoxybenzaldehyde is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Technology Process of 2-ISO-PROPOXYBENZALDEHYDE

There total 9 articles about 2-ISO-PROPOXYBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

salicylaldehyde (90-02-8) + isopropyl bromide (75-26-3) → 2-isopropoxybenzaldehyde (22921-58-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1002/chem.201802044

Reference yield: 95.0%

2-iodo-propane (75-30-9) + salicylaldehyde (90-02-8) → 2-isopropoxybenzaldehyde (22921-58-0)

Guidance literature:

With potassium carbonate;

DOI:10.1021/op300116j

Reference yield: 70.0%

1-bromo-2-isopropoxybenzene (701-07-5) → 2-isopropoxybenzaldehyde (22921-58-0)

Guidance literature:

upstream raw materials:

2-iodo-propane

salicylaldehyde

isopropyl bromide

2-methyl-benzyl alcohol

Downstream raw materials:

(E)-3-(2-isopropoxyphenyl)acrylic acid

2-isopropoxy-benzaldehyde-semicarbazone

o-isopropoxystyrene

2-isopropoxy-benzaldehyde O-methyloxime

Refernces

• 1、 Krause, Jens O.,Nuyken, Oskar,Wurst, Klaus,Buchmeiser, Michael R.. "Synthesis and Reactivity of Homogeneous and Heterogeneous Ruthenium-Based Metathesis Catalysts Containing Electron-Withdrawing Ligands". . p. 777 - 784. Retrieved 2004.
• 2、 Czajkowska-Szczykowska, Dorota,Czarnocki, Stefan,Grela, Karol,Kajetanowicz, Anna,Ma?ecki, Pawe?,Niena?towski, Tomasz,Paw?owska, Jolanta,Szczepanik, Pawe?. "Large-Scale Synthesis of a Niche Olefin Metathesis Catalyst Bearing an Unsymmetrical N-Heterocyclic Carbene (NHC) Ligand and its Application in a Green Pharmaceutical Context". supporting information. p. 15708 - 15717. Retrieved 2020/12/01.