Hypochlorous acid, phenyl ester

Base Information

• Chemical Name: Hypochlorous acid, phenyl ester
• CAS No.: 58061-19-1
• Molecular Formula: C6H5ClO
• Molecular Weight: 128.558
• Mol file: 58061-19-1.mol

Synonyms:

Chemical Property of Hypochlorous acid, phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hypochlorous acid, phenyl ester

There total 1 articles about Hypochlorous acid, phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-chloroacetanilide (579-11-3) + phenol (108-95-2,27073-41-2) → hypochlorous acid phenyl ester (58061-19-1) + Acetanilid (103-84-4)

Guidance literature:

With sodium hydroxide; disodium hydrogenphosphate; NaH₂PO₄-buffer; sodium perchlorate; In acetonitrile; at 39.4 ℃; Rate constant;

DOI:10.1021/jo00187a037

Reference yield:

trimethyl(prop-1-ynyl)silane (6224-91-5) + hypochlorous acid phenyl ester (58061-19-1) → 1-phenoxy-2-propyne (13610-02-1)

Guidance literature:

trimethyl(prop-1-ynyl)silane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

hypochlorous acid phenyl ester; In tetrahydrofuran; hexane; at 20 ℃; for 1h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1002/ejoc.202100423

Reference yield:

hypochlorous acid phenyl ester (58061-19-1) → (3-phenoxyprop-1-yn-1‐yl)benzene (92496-20-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; triethylamine / tetrahydrofuran / 0.08 h / Inert atmosphere

2.2: 12 h / Inert atmosphere; Reflux

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; triethylamine; In tetrahydrofuran; hexane;

DOI:10.1002/ejoc.202100423

upstream raw materials:

N-chloroacetanilide

phenol

Downstream raw materials:

(3-phenoxyprop-1-yn-1‐yl)benzene

1-phenoxy-2-propyne

Refernces