AZIDOPROPIONICACID

Base Information

• Chemical Name: AZIDOPROPIONICACID
• CAS No.: 79583-67-8
• Molecular Formula: C₃H₅N₃O₂
• Molecular Weight: 115.092
• Mol file: 79583-67-8.mol

Synonyms:18523-47-2;Azidopropionic acid;

Chemical Property of AZIDOPROPIONICACID

Chemical Property:

• PSA: 87.05000
• LogP: 0.22416

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AZIDOPROPIONICACID

There total 9 articles about AZIDOPROPIONICACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-Bromopropionic acid (590-92-1) → 3-azidopropanoic acid (18523-47-2,79583-67-8)

Guidance literature:

With sodium azide; In water;

DOI:10.1021/acsmedchemlett.5b00474

Reference yield: 99.0%

acrylic acid (79-10-7) → 3-azidopropanoic acid (18523-47-2,79583-67-8)

Guidance literature:

With trimethylsilylazide; In neat (no solvent); at 60 ℃; for 0.5h;

DOI:10.1021/ol302069h

Reference yield: 85.0%

chloropropionic acid (107-94-8) → 3-azidopropanoic acid (18523-47-2,79583-67-8)

Guidance literature:

With sodium azide; In water; for 15h;

DOI:10.1016/j.polymer.2014.01.026

upstream raw materials:

acrylic acid

β-Propiolactone

3-Bromopropionic acid

azido-b-alanine methyl ester

Downstream raw materials:

rhodamine 101 3-azido-1-(piperazin-1-yl)propan-1-one

rhodamine B 3-azido-1-(piperazin-1-yl)propan-1-one

C₁₈H₂₆N₆O₆S

C₄₄H₆₅N₁₁O₉

Refernces

• 1、 Zhao, Lei,Fan, Tingting,Shi, Zhichao,Ding, Chao,Zhang, Cunlong,Yuan, Zigao,Sun, Qinsheng,Tan, Chunyan,Chu, Bizhu,Jiang, Yuyang. "Design, synthesis and evaluation of novel ErbB/HDAC multitargeted inhibitors with selectivity in EGFRT790M mutant cell lines". . . Retrieved 2021/01/25.
• 2、 Chen, Deng,Cool, Robbert H.,Dekker, Frank J.,Melgert, Barbro N.,Poelarends, Gerrit J.,Quax, Wim J.,Song, Shanshan,Xiao, Zhangping,van Merkerk, Ronald,van der Wouden, Petra E.. "Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti-Proliferative Activity in Lung Cancer Cells". supporting information. p. 17514 - 17521. Retrieved 2021/07/02.