Propanoic acid, 3-azido-, methyl ester

Base Information

• Chemical Name: Propanoic acid, 3-azido-, methyl ester
• CAS No.: 23605-39-2
• Molecular Formula: C4H7N3O2
• Molecular Weight: 129.118
• Mol file: 23605-39-2.mol

Synonyms:

Chemical Property of Propanoic acid, 3-azido-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanoic acid, 3-azido-, methyl ester

There total 1 articles about Propanoic acid, 3-azido-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3-methoxypropionate (3852-09-3) + azido-b-alanine methyl ester (23605-39-2)

Guidance literature:

With sodium azide; oxygen; rhodamine B; In water; at 15 ℃; for 24h; Irradiation;

DOI:10.1007/s11164-012-0629-3

Reference yield: 97.0%

azido-b-alanine methyl ester (23605-39-2) + 3-acetylenephenylamine (54060-30-9) → methyl 3-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)propionate

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; water; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2016.07.033

Reference yield: 84.0%

azido-b-alanine methyl ester (23605-39-2) + 1-bromo-3-(prop-2-yn-1-yloxy)benzene (114855-35-5) → methyl 3-(4-((3-bromophenoxy)methyl)-1H-1,2,3-triazol-1-yl)propanoate

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 80 ℃; for 2h; Microwave irradiation;

DOI:10.1021/acs.jmedchem.6b01357

upstream raw materials:

methanol

acrylic acid methyl ester

Downstream raw materials:

3-azidopropanoic acid

C₂₁H₂₆N₄O₇

Refernces