DIMETHYLTHEXYLSILYL CHLORIDE

Base Information

• Chemical Name: DIMETHYLTHEXYLSILYL CHLORIDE
• CAS No.: 67373-56-2
• Molecular Formula: C8H19ClSi
• Molecular Weight: 178.777
• Hs Code.: 29319090
• Mol file: 67373-56-2.mol

Synonyms:Chlorodimethyl(1,1,2-trimethylpropyl)silane;Chlorodimethylthexylsilane;Dimethyl(1,1,2-trimethylpropyl)silyl chloride;Dimethylthexylsilyl chloride;Thexyldimethylchlorosilane;Thexyldimethylsilylchloride;Chloro(2,3-dimethylbutan-2-yl)dimethylsilane;

Chemical Property of DIMETHYLTHEXYLSILYL CHLORIDE

Chemical Property:

• Appearance/Colour: colorless liquid
• Vapor Pressure: 1.87mmHg at 25°C
• Melting Point: 15 °C
• Refractive Index: n20/D 1.449(lit.)
• Boiling Point: 171.3 °C at 760 mmHg
• Flash Point: 51.7 °C
• PSA: 0.00000
• Density: 0.858 g/cm³
• LogP: 3.86650
• Storage Temp.: Flammables area
• Sensitive.: Moisture Sensitive
• Solubility.: sol in THF, DMF, CH2Cl2.

Purity/Quality:

98%,99%, ^*data from raw suppliers

DimethylthexylsilylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 10-34-37
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Physical properties: mp 14–15 °C; bp 55–56 °C/10 mmHg; d 0.909 g cm?3.
• Uses: Silylating reagent for the protection of 1? and 2? alcohols and N-silylation of amines and amides; used in the preparation of thexyldimethylsilyl triflate; formation of α-silyl hydrazones; formylation of polyfluoroalkyl halides. Thexyldimethylsilyl chloride (TDS-Cl) was first introduced as a more easily prepared alternative to the more commonly used t-butyldimethylsilyl chloride for the protection of alcohols. Protecting reagent for alcohols and other functional groups. Employed in the synthesis of silicon naphthocyanine and cyclodextrin derivatives, which are useful as antitumor dyes and chiral stationary phases, respectively.

Technology Process of DIMETHYLTHEXYLSILYL CHLORIDE

There total 6 articles about DIMETHYLTHEXYLSILYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

chloro-trimethyl-silane (75-77-4) + 2,3-Dimethyl-2-butene (563-79-1) → chlorodimethyl(1,1,2-trimethylpropyl)silane (67373-56-2)

Guidance literature:

With zinc(II) chloride; at -10 - 0 ℃; for 7h; Reagent/catalyst;

Reference yield: 93.0%

2,3-Dimethyl-2-butene (563-79-1) + dimethylmonochlorosilane (1066-35-9) → chlorodimethyl(1,1,2-trimethylpropyl)silane (67373-56-2)

Guidance literature:

aluminium trichloride; In neat (no solvent); at 25 ℃; for 4h;

DOI:10.1016/S0040-4039(01)80873-X

Reference yield: 90.0%

hexamethylsilirane (55644-09-2) → chlorodimethyl(1,1,2-trimethylpropyl)silane (67373-56-2)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/S0022-328X(00)86821-7

upstream raw materials:

2,3-Dimethyl-2-butene

dimethylmonochlorosilane

dimethyl-(1,1,2-trimethylpropyl)silanol

hexamethylsilirane

Downstream raw materials:

(2R,3S)-cis-6-chloro-3-dimethyl(1,1,2-trimethylpropyl)siloxy-1-vinylcyclohexa-4,6-diene-2-ol

<2-(4-bromophenyl)ethoxy>dimethyl(1,1,2-trimethylpropyl)silane

4-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-methoxy-2-nitro-benzoyl chloride

1-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-phenyl}-4-(4-methoxy-benzyloxy)-but-2-yn-1-one

Refernces

• 1、 Savela, Risto,Zawartka, Wojciech,Leino, Reko. "Iron-catalyzed chlorination of silanes". experimental part. p. 3199 - 3206. Retrieved 2012/06/04.
• 2、 -. "Silanes, process for their preparation, and their use". . . Retrieved 2008/06/13.