Technology Process of Pyrazine, phenyl-, 4-oxide
There total 2 articles about Pyrazine, phenyl-, 4-oxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
maleic anhydride; dihydrogen peroxide;
In
dichloromethane;
1) r.t., overnight, 2) reflux, 2 h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 34 percent / KOH / ethanol / 5 h / Heating
2: 76 percent / 90percent H2O2, maleic anhydride / CH2Cl2 / 1) r.t., overnight, 2) reflux, 2 h
With
maleic anhydride; potassium hydroxide; dihydrogen peroxide;
In
ethanol; dichloromethane;
- Guidance literature:
-
With
potassium tert-butylate;
In
tetrahydrofuran;
at 80 ℃;
for 6h;
Sealed tube;
Inert atmosphere;
DOI:10.1021/acs.orglett.9b02365
