2-PHENYL-PYRAZINE

Base Information

• Chemical Name: 2-PHENYL-PYRAZINE
• CAS No.: 29460-97-7
• Molecular Formula: C10H8 N2
• Molecular Weight: 156.187
• Mol file: 29460-97-7.mol

Synonyms:Pyrazine,phenyl- (7CI,8CI,9CI); 2-Phenylpyrazine; Phenylpyrazine

Chemical Property of 2-PHENYL-PYRAZINE

Chemical Property:

• Vapor Pressure: 0.0082mmHg at 25°C
• Refractive Index: 1.58
• Boiling Point: 276.2°C at 760 mmHg
• Flash Point: 103.9°C
• PSA: 25.78000
• Density: 1.106g/cm³
• LogP: 2.14360

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Phenylpyrazine 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PHENYL-PYRAZINE

There total 67 articles about 2-PHENYL-PYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloropyrazin (14508-49-7) + phenylboronic acid (98-80-6) → 2-phenylpyrazine (29460-97-7)

Guidance literature:

With tetrabutyl ammonium fluoride; tricyclohexylphosphine; dichloro bis(acetonitrile) palladium(II); at 85 - 90 ℃; for 5h;

DOI:10.1080/00397910701412828

Reference yield: 98.0%

2-bromopyrazine (56423-63-3) + phenylboronic acid (98-80-6) → 2-phenylpyrazine (29460-97-7)

Guidance literature:

With sodium methylate; palladium diacetate; In methanol; at 20 ℃; for 5h; aerobic condition;

DOI:10.1002/ejoc.200600879

Reference yield: 95.0%

2-bromopyrazine (56423-63-3) + phenylzinc chloride (28557-00-8) → 2-phenylpyrazine (29460-97-7)

Guidance literature:

2-bromopyrazine; With potassium phosphate; C₅₄H₄₄NO₂PPdS; In tetrahydrofuran; at 0 ℃; for 0.0833333h; Inert atmosphere; Sealed tube;

phenylzinc chloride; In tetrahydrofuran; at 0 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b02414

upstream raw materials:

1,4-pyrazine

benzoic acid methyl ester

2-chloropyrazin

phenylboronic acid

Downstream raw materials:

3-phenylpyrazine-2-carbonitrile

5-Phenyl-2-pyrazinecarbonitrile

6-Phenyl-2-pyrazinecarbonitrile

Refernces

• 1、 -. "Anthracene-containing dimer skeleton ligand and preparation method thereof, and application in metal catalytic reaction". Paragraph 0143-0146. . Retrieved 2021/01/29.
• 2、 Fu, Leiqing,Cao, Xiaoji,Wan, Jie-Ping,Liu, Yunyun. "Synthesis of Enaminone-Pd(II) Complexes and Their Application in Catalysing Aqueous Suzuki-Miyaura Cross Coupling Reaction". . p. 254 - 258. Retrieved 2020/01/25.