7-Methyl-1,2,3,4-tetrahydroquinoline

Base Information

• Chemical Name: 7-Methyl-1,2,3,4-tetrahydroquinoline
• CAS No.: 58960-03-5
• Molecular Formula: C10H13N
• Molecular Weight: 147.22
• Hs Code.: 2933499090
• Mol file: 58960-03-5.mol

Synonyms:1,2,3,4-tetrahydro-7-methquinoline;7-methyl-1,2,3,4-tetrahydro-quinoline;7-Methyl-1.2.3.4-tetrahydro-chinolin;1,2,3,4-tetrahydro-7-methylquinoline;1,2,3,4-Tetrahydro-7-methylchinolin;

Chemical Property of 7-Methyl-1,2,3,4-tetrahydroquinoline

Chemical Property:

• Boiling Point: 263.1±25.0 °C(Predicted)
• PKA: 5.26±0.20(Predicted)
• PSA: 12.03000
• Density: 0.990±0.06 g/cm3(Predicted)
• LogP: 2.49110
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

7-methyl-1,2,3,4-tetrahydroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Methyl-1,2,3,4-tetrahydroquinoline

There total 19 articles about 7-Methyl-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

7-methylquinoline (612-60-2) + nickel (II) chloride hexahydrate → 7-methyl-1,2,3,4-tetrahydroquinoline (58960-03-5)

Guidance literature:

With hydrogenchloride; sodium borohydrid; In methanol;

Reference yield: 97.0%

7-methylquinoline (612-60-2) → 7-methyl-1,2,3,4-tetrahydroquinoline (58960-03-5)

Guidance literature:

With iridium(IV) oxide tetrahydrate; hydrogen; In methanol; at 60 ℃; for 24h; under 45603.1 Torr; Temperature; Pressure; regioselective reaction; Catalytic behavior;

DOI:10.1002/adsc.201601370

Reference yield: 85.0%

7-methylquinoline (612-60-2) → 7-methyl-1,2,3,4-tetrahydroquinoline (58960-03-5) + 7-methyl-5,6,7,8-tetrahydroquinoline (71350-24-8)

Guidance literature:

With hydrogen; platinum; In trifluoroacetic acid; Yield given. Title compound not separated from byproducts;

DOI:10.1007/BF00809353

upstream raw materials:

7-methylquinoline

2,4-dichloro-7-methylquinoline

tetralin

decalin

Downstream raw materials:

7-methylquinoline

aniline

4-methoxy-aniline

p-toluidine

Refernces

• 1、 Heizinger, Christian,Topf, Christoph,Vielhaber, Thomas. "Homogeneous pressure hydrogenation of quinolines effected by a bench-stable tungsten-based pre-catalyst". . p. 451 - 461. Retrieved 2021/11/11.
• 2、 Gao, Chao,Xuan, Qingqing,Song, Qiuling. "Cu-Catalyzed Chemoselective Reduction of N-Heteroaromatics with NH3·BH3 in Aqueous Solution". supporting information. p. 2504 - 2508. Retrieved 2021/07/31.