7-Methylquinoline

Base Information

• Chemical Name: 7-Methylquinoline
• CAS No.: 612-60-2
• Molecular Formula: C10H9N
• Molecular Weight: 143.188
• Hs Code.: 29334900
• European Community (EC) Number: 210-316-2
• NSC Number: 65665
• UN Number: 1760
• UNII: EOW995K43C
• DSSTox Substance ID: DTXSID5025657
• Nikkaji Number: J842G
• Wikidata: Q27277283
• ChEMBL ID: CHEMBL1322524
• Mol file: 612-60-2.mol

Synonyms:7-METHYLQUINOLINE;612-60-2;m-Toluquinoline;Quinoline, 7-methyl-;7-methyl-Quinoline;CCRIS 2895;EINECS 210-316-2;NSC 65665;BRN 0110317;UNII-EOW995K43C;AI3-00850;EOW995K43C;DTXSID5025657;MFCD00006805;NSC-65665;Quinolinol,7-Methyl-;5-20-07-00402 (Beilstein Handbook Reference);7-methyl quinoline;NSC65665;7-Methylquinoline, 97%;METHYLQUINOLINE, 7-;NCIOpen2_000315;SCHEMBL12361;DTXCID005657;CHEMBL1322524;BCP32568;Tox21_201146;BBL102502;STL556305;AKOS005206837;LS-1464;NCGC00091608-01;NCGC00091608-02;NCGC00258698-01;AM807084;AS-12675;CAS-612-60-2;FT-0621465;M0417;M1180;EN300-97214;I11486;A833132;J-517831;W-105171;Q27277283;F0001-2460;12-60-2

Chemical Property of 7-Methylquinoline

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.0275mmHg at 25°C
• Melting Point: 35-37 °C(lit.)
• Refractive Index: 1.624
• Boiling Point: 254.5 °C at 760 mmHg
• PKA: 5.44±0.14(Predicted)
• Flash Point: 104.4 °C
• PSA: 12.89000
• Density: 1.076 g/cm³
• LogP: 2.54320
• Storage Temp.: Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility.: <0.1 g/100 mL at 20℃
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 143.073499291
• Heavy Atom Count: 11
• Complexity: 133
• Transport DOT Label: Corrosive

Purity/Quality:

99% ^*data from raw suppliers

m-Toluquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Quinolines
• Canonical SMILES: CC1=CC2=C(C=CC=N2)C=C1
• Uses: 7-methylquinoline has been bioassayed as tumor initiator on the skin of Sencar mice.

Technology Process of 7-Methylquinoline

There total 33 articles about 7-Methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

7-methyl-1,2,3,4-tetrahydroquinoline (58960-03-5) + nitrobenzene (98-95-3,26969-40-4) → 7-methylquinoline (612-60-2) + aniline (62-53-3)

Guidance literature:

With nickel-nitrogen-doped carbon framework; In water; at 145 ℃; for 18h; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1039/c9gc04358f

Reference yield: 94.0%

7-methyl-1,2,3,4-tetrahydroquinoline (58960-03-5) + 1-methyl-4-nitrobenzene (99-99-0) → 7-methylquinoline (612-60-2) + p-toluidine (106-49-0,12221-03-3)

Guidance literature:

With nickel-nitrogen-doped carbon framework; In water; at 145 ℃; for 18h; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1039/c9gc04358f

Reference yield: 92.0%

7-methyl-1,2,3,4-tetrahydroquinoline (58960-03-5) → 7-methylquinoline (612-60-2)

Guidance literature:

With copper(I) oxide; dmap; N-hydroxyphthalimide; oxygen; In acetonitrile; at 120 ℃; for 12h; Sealed tube;

DOI:10.1002/adsc.202000767

upstream raw materials:

allyl alcohol

3-Methylcyclohexanone

glycerol

1-amino-3-methylbenzene

Downstream raw materials:

2-(4-chloro-phenyl)-7-methyl-quinoline

2-(4-methoxy-phenyl)-7-methyl-quinoline

N,N-dimethyl-4-(7-methyl-quinolin-2-yl)-aniline

quinoline-7-carbaldehyde

Refernces

• 1、 Chen, Weidong,Tang, Hao,Wang, Weilin,Fu, Qiang,Luo, Junfei. "Catalytic Aerobic Dehydrogenatin of N-Heterocycles by N-Hydoxyphthalimide". supporting information. p. 3905 - 3911. Retrieved 2020/08/10.
• 2、 Duan, Zhiying,Liu, Fangfang,Pang, Shaofeng,Su, Qiong,Wang, Yanbin,Xie, Xin,Zhang, Ping,Zhang, Yujing,Zhou, Feng. "Superhydrophobic nickel/carbon core-shell nanocomposites for the hydrogen transfer reactions of nitrobenzene and N-heterocycles". . p. 1996 - 2010. Retrieved 2020/04/07.