1-(4-methylbenzoyl)pyrrolidine

Base Information

• Chemical Name: 1-(4-methylbenzoyl)pyrrolidine
• CAS No.: 59746-40-6
• Molecular Formula: C12H15NO
• Molecular Weight: 189.257
• Mol file: 59746-40-6.mol

Synonyms:pyrrolidine hydrochloride;pyrrolidinium chloride;axetidine hydrochloride;Pyrrolidin-1-thiocarbonsaeure-aethylamid;pyrrolidin hydrochloride;pyrrolidinium hydrochloride;pyrrolidine hydrochloride salt;pyrrolidin-1-ium chloride;pyrrolidin-1-yl-4-tolylmethanone;pyrrolidine-1-carbothioic acid ethylamide;

Chemical Property of 1-(4-methylbenzoyl)pyrrolidine

Chemical Property:

• PSA: 20.31000
• LogP: 2.16890

Purity/Quality:

99% ^*data from raw suppliers

1-(4-methylbenzoyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-methylbenzoyl)pyrrolidine

There total 22 articles about 1-(4-methylbenzoyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyrrolidine (123-75-1) + N,4-dimethyl-N-tosylbenzamide → pyrrolidin-1-yl(p-tolyl)methanone (59746-40-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.3762/bjoc.11.138

Reference yield: 99.0%

trifluoro(pyrrolidin-1-ium-1-ylidene(p-tolyl)methyl)borate → pyrrolidin-1-yl(p-tolyl)methanone (59746-40-6)

Guidance literature:

With dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; In water; acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1039/d0sc01330g

Reference yield: 96.0%

pyrrolidine (123-75-1) + p-Toluic acid (99-94-5) → pyrrolidin-1-yl(p-tolyl)methanone (59746-40-6)

Guidance literature:

p-Toluic acid; With N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-N-ethynylmethanesulfonamide; In dichloromethane; at 20 ℃;

pyrrolidine; In dichloromethane;

upstream raw materials:

pyrrolidine

4-methyl-benzoyl chloride

para-bromotoluene

p-Toluic acid

Downstream raw materials:

pyrrolidine

p-Toluic acid

p-(1-pyrrolidinyl)carbonylbenzaldehyde

5-methyl-2-phenylisoindoline-1,3-dione

Refernces

• 1、 Gao, Pengpeng,Zhang, Xiaohui,Zheng, Qing-Zhong. "Cobalt(iii)-catalyzed C-H amidation of: N, N -dialkyl thiobenzamides by sulfur coordination". supporting information. p. 10332 - 10336. Retrieved 2021/12/17.
• 2、 Liu, Tao,Zhang, Xue,Peng, Zejun,Zhao, Junfeng. "Water-removable ynamide coupling reagent for racemization-free syntheses of peptides, amides, and esters". supporting information. p. 9916 - 9921. Retrieved 2021/12/24.