4-(PYRROLIDINE-1-CARBONYL)-BENZALDEHYDE

Base Information

• Chemical Name: 4-(PYRROLIDINE-1-CARBONYL)-BENZALDEHYDE
• CAS No.: 80020-05-9
• Molecular Formula: C12H13 N O2
• Molecular Weight: 203.241
• Hs Code.: 2933990090
• Mol file: 80020-05-9.mol

Synonyms:Pyrrolidine,1-(4-formylbenzoyl)- (9CI); 4-(1-Pyrrolidinylcarbonyl)benzaldehyde;4-Pyrrolidinocarbonylbenzaldehyde

Chemical Property of 4-(PYRROLIDINE-1-CARBONYL)-BENZALDEHYDE

Chemical Property:

• PSA: 37.38000
• LogP: 1.67300

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(Pyrrolidine-1-carbonyl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(PYRROLIDINE-1-CARBONYL)-BENZALDEHYDE

There total 5 articles about 4-(PYRROLIDINE-1-CARBONYL)-BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

pyrrolidine (123-75-1) + terephthalaldehyde, (623-27-8) → p-(1-pyrrolidinyl)carbonylbenzaldehyde (80020-05-9)

Guidance literature:

With 36.64% Cd(II) immobilized on amine-functionalized magnetic nano-Fe3O4 nanocomposite; In acetonitrile; at 20 ℃; for 16h; Irradiation;

DOI:10.1002/chem.202005138

Reference yield: 78.0%

pyrrolidine (123-75-1) + 4-formylbenzoic anhydride (69897-42-3) → p-(1-pyrrolidinyl)carbonylbenzaldehyde (80020-05-9)

Guidance literature:

4-formylbenzoic anhydride; With methanesulfonyl chloride; triethylamine; In dichloromethane; at -78 ℃; for 0.5h; Inert atmosphere;

pyrrolidine; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1055/s-0037-1609564

Reference yield: 43.0%

pyrrolidin-1-yl(p-tolyl)methanone (59746-40-6) → p-(1-pyrrolidinyl)carbonylbenzaldehyde (80020-05-9)

Guidance literature:

With dirhodium tetraacetate; Selectfluor; In trifluoroacetic acid; trifluoroacetic anhydride; at 110 ℃; for 7h; chemoselective reaction; Sealed tube; Inert atmosphere;

DOI:10.1002/chem.201502140

upstream raw materials:

pyrrolidine

4-Carboxybenzaldehyde

terephthalaldehyde,

pyrrolidin-1-yl(p-tolyl)methanone

Downstream raw materials:

diethyl [2-(4-(4-chlorobenzoyl)-2-oxo-1-(4-(1-pyrrolidinecarbonyl)benzyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]-diazepin-8-yl)ethyl]phosphonate

Refernces

• 1、 Kumar, Varun,Kumar, Yashwant,Lal Meena, Chhuttan,Mahajan, Dinesh,Rana, Anil,Sharma, Nidhi. "Electrophilic Activation of Carboxylic Anhydrides for Nucleophilic Acylation Reactions". . p. 3902 - 3910. Retrieved 2018/09/29.
• 2、 Li, Gai-Li,Kung, Karen Ka-Yan,Wong, Man-Kin. "Gold-catalyzed amide synthesis from aldehydes and amines in aqueous medium". supporting information; experimental part. p. 4112 - 4114. Retrieved 2012/06/16.