Bromo propoinic acid

Base Information

• Chemical Name: Bromo propoinic acid
• CAS No.: 600-31-7
• Molecular Formula: C3H3BrO4
• Molecular Weight: 182.958
• Hs Code.: 2917190090
• Mol file: 600-31-7.mol

Synonyms:Propanedioic acid, bromo-;2-bromopropanedioic acid;

Chemical Property of Bromo propoinic acid

Chemical Property:

• Vapor Pressure: 5.73E-06mmHg at 25°C
• Melting Point: 91-95°C
• Boiling Point: 354.2oC at 760 mmHg
• Flash Point: 168oC
• PSA: 74.60000
• Density: 2.262g/cm3
• LogP: -0.08090
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO, Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

2-Bromopropanedioic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromopropanedioic Acid is an analog of the competitive inhibitor, malonate. Inhibitory activity towards Isocitrate lyase

Technology Process of Bromo propoinic acid

There total 8 articles about Bromo propoinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

malonic acid (141-82-2) → 2-bromomalonic acid (600-31-7)

Guidance literature:

With bromine; In diethyl ether;

DOI:10.1039/DT9900000207

Reference yield: 80.0%

malonic acid (141-82-2) + 2-bromo-2,5-di(N-pyridinium)-5-cyclohexene-1,3,4-trione-6-oxide betaine perbromide → 2-bromomalonic acid (600-31-7)

Guidance literature:

In diethyl ether; at 20 ℃; for 2h;

DOI:10.1007/BF02290722

Reference yield:

dibromomalonic acid (595-45-9) → malonic acid (141-82-2) + 2-bromomalonic acid (600-31-7)

Guidance literature:

With sodium amalgam; in waessr. Loesung;

upstream raw materials:

malonic acid

dibromomalonic acid

thiophenol

Diethyl 2-bromomalonate

Downstream raw materials:

dimethyl 2-bromomalonate

succinic acid anhydride

diphenyldisulfane

2-bromo-1-(4-methoxyphenyl)-1-phenylethene

Refernces

• 1、 Matsumura-Inoue, Takeko,Nakamura, Tatsuhito,Mori, Yoshihito,Hanazaki, Ichiro. "Effect of pulsed illumination on the belousov-zhabotinsky reaction catalyzed with tris(bipyridine) ruthenium(II) in continuous stirred tank reactor". . p. 1237 - 1238. Retrieved 1999.
• 2、 Dechert, G.,Lebender, D.,Schneider, F. W.. "Electrical Pulses To Determine Chemical Phase Response Curves". . p. 11432 - 11435. Retrieved 1995.
• 3、 Zhabotinsky, Anatol M.,Gyoergyi, Laszlo,Dolnik, Milos,Epstein, Irving R.. "Stratification in a Thin-Layered Excitable Reaction-Diffusion System with Transverse Concentration Gradients". . p. 7981 - 7990. Retrieved 1994.
• 4、 Kuhnert, L.,Krug, H.-J.. "Kinetics of Chemical Waves in the Acidic Bromate-Malonic Acid-Ru(bpy)32+ System in Comparison with the Ferroin System". . p. 730 - 733. Retrieved 1987.
• 5、 Rodriguez, J.,Vidal, C.. "Measurement of Convection Velocities in "Mosaic" Patterns". . p. 2737 - 2740. Retrieved 1989.
• 6、 Alba, Francesca D',Lorenzi, Sergio Di. "Some Statements Concerning Oscillatory Phenomena". . p. 39 - 54. Retrieved 1983.
• 7、 Aliev, R. R.,Rovinsky, A. B.. "Spiral Waves in the Homogeneous and Inhomogeneous Belousov-Zhabotinsky Reaction". . p. 732 - 736. Retrieved 1992.
• 8、 Yanchishin,Karlivan,Valter. "Synthesis and properties of dipyridemium betaines of derivatives of 1,4-benzoquinone and tetracyanoquinodimethane". . p. 312 - 315. Retrieved 1998.
• 9、 Hassan, Heba A.,Abdel-Aziz, Mohamed,Abuo-Rahma, Gamal El-Din A.A.,Farag, Hassan H.. "1-Malonyl-1,4-dihydropyridine as a novel carrier for specific delivery of drugs to the brain". body text. p. 1681 - 1692. Retrieved 2009/08/07.