Acetic acid 4-(2-hydroxyethyl)phenyl ester

Base Information

• Chemical Name: Acetic acid 4-(2-hydroxyethyl)phenyl ester
• CAS No.: 60037-43-6
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Hs Code.: 2915390090
• Mol file: 60037-43-6.mol

Synonyms:Benzeneethanol,4-(acetyloxy);2-(4-methylcarbonyloxyphenyl)-1-ethanol;4'-acetoxyphenylmethylcarbinol;4-Hydroxyethylacetoxybenzene;2-(4-acetoxyphenyl)ethanol;4-(2-Hydroxyethyl)phenyl acetate;4-acetoxyphenethyl alcohol;Acetic acid 4-(2-hydroxyethyl)phenyl ester;2-(p-acetoxy-phenyl)-ethanol;

Chemical Property of Acetic acid 4-(2-hydroxyethyl)phenyl ester

Chemical Property:

• PSA: 46.53000
• LogP: 1.14670
• Storage Temp.: Room Temperature
• Solubility.: Dichloromethane; Diethyl Ether

Purity/Quality:

2-(4-Acetoxyphenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(4-Acetoxyphenyl)ethanol is an intermediate in synthesizing Oleocanthal (O524540). It is a compound of olive oil with potential use as anti-inflammatory and chemotherapeutic agents.

Technology Process of Acetic acid 4-(2-hydroxyethyl)phenyl ester

There total 21 articles about Acetic acid 4-(2-hydroxyethyl)phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.1%

vinyl acetate (108-05-4,9003-20-7) + p-hydroxyphenethyl alcohol (501-94-0) → 2-(4-acetoxyphenyl)ethanol (60037-43-6) + 2-(4-acetoxyphenyl)ethyl acetate (60037-42-5)

Guidance literature:

With rubidium fluoride; In acetonitrile; at 80 ℃; for 0.5h; Reagent/catalyst;

DOI:10.1007/s00706-013-1019-2

Reference yield: 90.0%

p-hydroxyphenethyl alcohol (501-94-0) + acetic anhydride (108-24-7) → 2-(4-acetoxyphenyl)ethanol (60037-43-6)

Guidance literature:

With sodium hydroxide; In water; at 0 - 10 ℃; for 1.66667h; pH=7 - 8; Large scale reaction;

DOI:10.1080/00397911.2010.515332

Reference yield: 90.0%

p-hydroxyphenethyl alcohol (501-94-0) + 1-acetyl-1H-1,2,3-triazolo<4,5-b>pyridine (107866-54-6) → 2-(4-acetoxyphenyl)ethanol (60037-43-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; for 0.5h; Ambient temperature;

DOI:10.1016/S0040-4039(00)85125-4

upstream raw materials:

p-hydroxyphenethyl alcohol

1-acetyl-1H-1,2,3-triazolo<4,5-b>pyridine

acetic anhydride

4-Methoxyphenylacetic acid

Downstream raw materials:

2,5-bis(4-acetoxy-3,5-dibromobenzoyl)-3,4-bis(4-acetoxy-3,5-dibromophenyl)-1-[2-(4-acetoxyphenyl)ethyl]-1H-pyrrole

(2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-(4-acetoxyphenethoxy)tetrahydro-2Hpyran-3,4,5-triyl triacetate

(4-acetoxyphenyl)acetaldehyde

Salidroside

Refernces

• 1、 -. "Preparation method for synthesis of phenolic ester through thiocarboxylic acid mediated visible light catalyzed phenol acylation reaction". Paragraph 0079; 0080; 0109; 0110; 0111. . Retrieved 2018/07/30.
• 2、 Mastihubová, Mária,Poláková, Monika. "A selective and mild glycosylation method of natural phenolic alcohols". . p. 524 - 530. Retrieved 2016/04/08.