4-(2-Acetoxy-ethyl)phenyl Acetate

Base Information

• Chemical Name: 4-(2-Acetoxy-ethyl)phenyl Acetate
• CAS No.: 60037-42-5
• Molecular Formula: C12H14O4
• Molecular Weight: 222.241
• Mol file: 60037-42-5.mol

Synonyms:2-(4-acetoxyphenyl)ethyl acetate;tyrosyl diacetate;Benzeneethanol,4-(acetyloxy)-,acetate;4-[2-(acetyloxy)ethyl]phenyl acetate;4.12-Diacetoxy-1-aethyl-benzol;1-acetoxy-4-(2-acetoxy-ethyl)-benzene;Diacetyl-1,4-tyrosol;2-(p-acetoxyphenyl)ethyl acetate;

Chemical Property of 4-(2-Acetoxy-ethyl)phenyl Acetate

Chemical Property:

• PSA: 83.83000
• LogP: 1.23760
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol, Hexane

Purity/Quality:

4-(2-Acetoxy-ethyl)phenylAcetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Tyrosol (T947800) derivative, phenolic antioxidant.

Technology Process of 4-(2-Acetoxy-ethyl)phenyl Acetate

There total 21 articles about 4-(2-Acetoxy-ethyl)phenyl Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-hydroxyphenethyl alcohol (501-94-0) + acetic anhydride (108-24-7) → 2-(4-acetoxyphenyl)ethyl acetate (60037-42-5)

Guidance literature:

With pyridine; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b03233

Reference yield: 98.0%

p-hydroxyphenethyl alcohol (501-94-0) + 2-acetyl-4,5-dichloropyridazin-3(2H)-one (155164-63-9) → 2-(4-acetoxyphenyl)ethyl acetate (60037-42-5)

Guidance literature:

p-hydroxyphenethyl alcohol; With aluminum (III) chloride; In tetrahydrofuran; for 0.0166667h;

2-acetyl-4,5-dichloropyridazin-3(2H)-one; In tetrahydrofuran; at 20 ℃; for 0.166667h;

DOI:10.1055/s-0034-1378335

Reference yield: 93.1%

vinyl acetate (108-05-4,9003-20-7) + p-hydroxyphenethyl alcohol (501-94-0) → 2-(4-acetoxyphenyl)ethanol (60037-43-6) + 2-(4-acetoxyphenyl)ethyl acetate (60037-42-5)

Guidance literature:

With rubidium fluoride; In acetonitrile; at 80 ℃; for 0.5h; Reagent/catalyst;

DOI:10.1007/s00706-013-1019-2

upstream raw materials:

p-hydroxyphenethyl alcohol

acetyl chloride

1-acetyl-1H-1,2,3-triazolo<4,5-b>pyridine

acetic anhydride

Downstream raw materials:

p-hydroxyphenethyl alcohol

2-(4-hydroxyphenyl)ethyl acetate

Refernces

• 1、 Temperini, Andrea,Minuti, Lucio,Morini, Tommaso,Rosati, Ornelio,Piazzolla, Francesca. "Isopropenyl acetate: A cheap and general acylating agent of alcohols under metal-free conditions". . p. 4051 - 4053. Retrieved 2017/09/27.
• 2、 Rajabi, Fatemeh,Luque, Rafael. "Solventless acetylation of alcohols and phenols catalyzed by supported iron oxide nanoparticles". . p. 129 - 132. Retrieved 2014/01/06.