4-PHENYL-1(2H)-PHTHALAZINONE

Base Information

• Chemical Name: 4-PHENYL-1(2H)-PHTHALAZINONE
• CAS No.: 5004-45-5
• Molecular Formula: C14H10N2O
• Molecular Weight: 222.246
• Hs Code.: 29339900
• Mol file: 5004-45-5.mol

Synonyms:1-Hydroxy-4-phenylphthalazine;4-Phenyl-1(2H)-phthalazinone;4-Phenyl-2H-phthalazin-1-one;4-Phenylphthalazin-1-one;NSC 59;4-phenylphthalazin-1(2H)-one;

Chemical Property of 4-PHENYL-1(2H)-PHTHALAZINONE

Chemical Property:

• Vapor Pressure: 6.65E-10mmHg at 25°C
• Melting Point: 240-244 °C(lit.)
• Refractive Index: 1.663
• Boiling Point: 481.7 °C at 760 mmHg
• PKA: 11.85±0.40(Predicted)
• Flash Point: 245.1 °C
• PSA: 45.75000
• Density: 1.24 g/cm³
• LogP: 2.59010

Purity/Quality:

98%min ^*data from raw suppliers

4-Phenylphthalazin-1(2H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-Phenyl-1-(2H)-phthalazinone may be used in the synthesis of 2-chloro-N-(unsubstituted/substitutedphenyl) acetamide.

Technology Process of 4-PHENYL-1(2H)-PHTHALAZINONE

There total 39 articles about 4-PHENYL-1(2H)-PHTHALAZINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Benzoylbenzoic acid (85-52-9) → 4-phenyl-2H-phthalazin-1-one (5004-45-5)

Guidance literature:

With sodium acetate; hydrazinium sulfate; In water;

DOI:10.1021/jm00350a018

Reference yield: 95.0%

2-benzoyl-benzoic acid N',N'-dimethyl-hydrazide → 4-phenyl-2H-phthalazin-1-one (5004-45-5)

Guidance literature:

With hydrazine; at 100 ℃; for 2h;

Reference yield: 95.0%

2-(Dimethylamino)-3-hydroxy-3-phenyl-2,3-dihydroisoindol-1-one (28352-78-5) → 4-phenyl-2H-phthalazin-1-one (5004-45-5)

Guidance literature:

With hydrazine hydrate; at 100 ℃; for 2h;

DOI:10.1055/s-2001-10804

upstream raw materials:

2-Benzoylbenzoic acid

1-aminoguanidine hydrochloride

2,3-dihydro-9b-phenyloxazolo<2,3-a>isoindol-5(9bH)-one

3-hydroxy-2,3-diphenyl-1-isoindolinone

Downstream raw materials:

4-phenylphthalazine-1(2H)-thione

2-(2-diethylamino-ethyl)-4-phenyl-2H-phthalazin-1-one

4-[2-[4-phenyl-1-oxo-1,2-dihydrophthalazin-2-yl]ethoxy]benzaldehyde

1-(N-Methylpiperazin-1-yl)-4-phenylphthalazine

Refernces

• 1、 El-Adl, Khaled,Ibrahim, Mohamed-Kamal,Khedr, Fathalla,Abulkhair, Hamada S.,Eissa, Ibrahim H.. "N-Substituted-4-phenylphthalazin-1-amine-derived VEGFR-2 inhibitors: Design, synthesis, molecular docking, and anticancer evaluation studies". . . Retrieved 2020/12/14.
• 2、 Nozawa-Kumada, Kanako,Matsuzawa, Yuta,Ono, Kanako,Shigeno, Masanori,Kondo, Yoshinori. "Copper-catalyzed aerobic double functionalization of benzylic C(sp3)-H bonds for the synthesis of 3-hydroxyisoindolinones". supporting information. p. 8604 - 8607. Retrieved 2021/09/02.