1,2-Cycloheptanedicarboxylic acid, trans-

Base Information

• Chemical Name: 1,2-Cycloheptanedicarboxylic acid, trans-
• CAS No.: 6070-46-8
• Molecular Formula: C₉H₁₄O₄
• Molecular Weight: 186.208
• Mol file: 6070-46-8.mol

Synonyms:

Chemical Property of 1,2-Cycloheptanedicarboxylic acid, trans-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-Cycloheptanedicarboxylic acid, trans-

There total 14 articles about 1,2-Cycloheptanedicarboxylic acid, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(+/-)-trans-2-acetyl-cycloheptanecarboxylic acid (99181-53-0) → trans-cycloheptane-1,2-dicarboxylic acid (3603-86-9,3603-87-0,6070-46-8,123005-74-3)

Guidance literature:

With sodium hypochlorite; sodium hydroxide; In water; for 0.5h; Cooling;

DOI:10.1021/acs.orglett.0c01184

Reference yield:

cis-cycloheptane-1,2-dicarboxylic acid (3603-86-9) → trans-cycloheptane-1,2-dicarboxylic acid (3603-86-9,3603-87-0,6070-46-8,123005-74-3)

Guidance literature:

With sulfuric acid; at 150 ℃;

DOI:10.1021/jo01041a006

Reference yield:

Cyclohept-2-en-1,2-dicarbonsaeure (3603-85-8) → trans-cycloheptane-1,2-dicarboxylic acid (3603-86-9,3603-87-0,6070-46-8,123005-74-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, aq. NaOH / Raney-Ni / 125 °C / 77572.2 Torr

2: aq. H₂SO₄ / 150 °C

With sodium hydroxide; sulfuric acid; hydrogen; nickel;

DOI:10.1021/jo01041a006

upstream raw materials:

cyclohept-1-enecarbonitrile

potassium cyanide

(+/-)-trans-2-acetyl-cycloheptanecarboxylic acid

cis-cycloheptane-1,2-dicarboxylic acid

Downstream raw materials:

trans-cycloheptane-1,2-dicarboxylic acid

(1S,2S)-cycloheptane-1,2-diol

(+/-)-trans-2-phenylacetyl-cycloheptanecarboxylic acid

Refernces