1-(4-NITROPHENYL)PYRROLIDINE

Base Information

• Chemical Name: 1-(4-NITROPHENYL)PYRROLIDINE
• CAS No.: 10220-22-1
• Molecular Formula: C10H12N2O2
• Molecular Weight: 192.217
• Hs Code.: 2933990090
• Mol file: 10220-22-1.mol

Synonyms:Pyrrolidine,1-(p-nitrophenyl)- (6CI,7CI,8CI);1-(4-Nitrophenyl)pyrrolidine;1-(p-Nitrophenyl)pyrrolidine;4-Pyrrolidinonitrobenzene;N-(4-Nitrophenyl)pyrrolidine;NSC 525710;p-(1-Pyrrolidinyl)nitrobenzene;

Chemical Property of 1-(4-NITROPHENYL)PYRROLIDINE

Chemical Property:

• Melting Point: 167-169 °C
• Boiling Point: 349.9 °C at 760 mmHg
• PKA: 1.30±0.40(Predicted)
• Flash Point: 165.4 °C
• PSA: 49.06000
• Density: 1.233 g/cm³
• LogP: 2.78320

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Nitrophenyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-NITROPHENYL)PYRROLIDINE

There total 40 articles about 1-(4-NITROPHENYL)PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyrrolidine (123-75-1) + 4-chlorobenzonitrile (100-00-5) → 1-(4-nitro-phenyl)-pyrrolidine (10220-22-1)

Guidance literature:

In tetrahydrofuran; at 50 ℃; for 20h; under 4500360 Torr;

DOI:10.1246/bcsj.64.42 DOI:10.1246/cl.1987.1187

Reference yield: 100.0%

pyrrolidine (123-75-1) + para-nitrophenyl bromide (586-78-7) → 1-(4-nitro-phenyl)-pyrrolidine (10220-22-1)

Guidance literature:

In tetrahydrofuran; at 50 ℃; for 20h; under 6375510 Torr;

DOI:10.1246/bcsj.64.42

Reference yield: 100.0%

pyrrolidine (123-75-1) + p-nitrobenzene iodide (636-98-6) → 1-(4-nitro-phenyl)-pyrrolidine (10220-22-1)

Guidance literature:

In tetrahydrofuran; at 50 ℃; for 20h; under 9000720 Torr;

DOI:10.1246/bcsj.64.42 DOI:10.1246/cl.1987.1187

upstream raw materials:

pyrrolidine

4-chlorobenzonitrile

p-nitrobenzene iodide

para-nitrophenyl triflate

Downstream raw materials:

4-pyrrolidin-1-yl-aniline

1-(4-isothiocyanatophenyl)pyrrolidine

1-(4-nitrophenyl)-2-pyrrolidinecarbonitrile

4-(4-(pyrrolidin-1-yl)phenylamino)-4-oxobutanoic acid

Refernces

• 1、 Srivastava, Avinash K.,Sharma, Charu,Joshi, Raj K.. "Cp*Co(iii) and Cu(OAc)2bimetallic catalysis for Buchwald-type C-N cross coupling of aryl chlorides and amines under base, inert gas & solvent-free conditions". . p. 8248 - 8253. Retrieved 2020.
• 2、 Nasir Baig,Varma, Rajender S.. "Magnetic silica supported copper: A modular approach to aqueous Ullmann-type amination of aryl halides". . p. 6568 - 6572. Retrieved 2014.
• 3、 Li, Hong Bo,Liang, Wu,Liu, Lang,Chen, Kai,Wu, Yi. "Microwave-assisted convenient synthesis of N-arylpyrrolidines in water". . p. 276 - 279. Retrieved 2011.
• 4、 Sellers,C.,Suschitzky,H.. "-". . p. 6186 - 6188. Retrieved 1965.
• 5、 Zarnaghash, Narges,Panahi, Farhad,Khalafi-Nezhad, Ali. "Buchwald-Hartwig amination reaction using supported palladium on phosphine-functionalized magnetic nanoparticles". . p. 2057 - 2064. Retrieved 2015.
• 6、 Singh, Sunil Kumar,Srinivasa Reddy,Mangle, Mangesh,Ravi Ganesh. "Cu(I)-mediated deoxygenation of N-oxides to amines". . p. 126 - 130. Retrieved 2007.
• 7、 Tohda, Yasuo,Ariga, Masahiro,Kawashima, Toshihide,Matsumura, Eizo. "ANIONIC ?-ADDUCTS OF 1-METHYL-3,5-DINITRO-2-PYRIDONE". . p. 715 - 718. Retrieved 1983.
• 8、 Zhang, Li,Wu, Yuhang,Yang, Guixiang,Gan, Haixian,Sang, Dayong,Zhou, Jiye,Su, Lin,Wang, Rui,Ma, Lei. "Design, synthesis and biological evaluation of novel osthole-based derivatives as potential neuroprotective agents". . . Retrieved 2020.
• 9、 Asahara, Haruyasu,Yasuoka, Azusa,Nishiwaki, Nagatoshi. "Activation of 1-methyl-5-nitro-2-pyrimidinone by dearomatization using a secondary amine". . p. 253 - 259. Retrieved 2018.
• 10、 -. "Ligand compound for copper catalyzed aryl halide coupling reaction, catalytic system and coupling reaction". Paragraph 0086-0091; 0094. . Retrieved 2021/05/29.