Bis[(2-diphenylphosphino)ethyl]ammonium chloride, min. 97%

Base Information

• Chemical Name: Bis[(2-diphenylphosphino)ethyl]ammonium chloride, min. 97%
• CAS No.: 66534-97-2
• Molecular Formula: C28H29NP2
• Molecular Weight: 477.953
• Hs Code.: 2932190090
• Mol file: 66534-97-2.mol

Synonyms:bis[(2-diphenylphosphino)ethyl]amine hydrochloride;Ethanamine,2-(diphenylphosphino)-N-[2-(diphenylphosphino)ethyl]-,hydrochloride;BIS[(2-DIPHENYLPHOSPHINO)ETHYL]AMMONIUM CHLORIDE;N,N-bis(diphenylphosphino-ethyl)-amine*HCl;

Chemical Property of Bis[(2-diphenylphosphino)ethyl]ammonium chloride, min. 97%

Chemical Property:

• Vapor Pressure: 7.3E-13mmHg at 25°C
• Melting Point: 175-180℃
• Boiling Point: 566.7°Cat760mmHg
• Flash Point: 296.6°C
• PSA: 39.21000
• Density: g/cm³
• LogP: 6.03470
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air Sensitive
• Water Solubility.: Insoluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

Bis[(2-diphenylphosphino)ethyl]ammonium chloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is involved in the Synthesis of the new chiral aminodiphosphine ligands.

Technology Process of Bis[(2-diphenylphosphino)ethyl]ammonium chloride, min. 97%

There total 4 articles about Bis[(2-diphenylphosphino)ethyl]ammonium chloride, min. 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + diphenylphosphane (829-85-6) → bis(2-(diphenylphosphino)ethyl)amine hydrochloride (66534-97-2)

Guidance literature:

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; for 16h; Heating;

DOI:10.1021/jo00327a005

Reference yield:

N,N-bis(chloro-2-ethyl)amine (334-22-5) + lithium diphenylphosphide (65567-06-8,4541-02-0) → bis(2-(diphenylphosphino)ethyl)amine hydrochloride (66534-97-2)

Guidance literature:

With lithium; In tetrahydrofuran; for 24h; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1002/aoc.6092

Reference yield:

N,N-bis(2-chloroethyl)-1,1,1-trimethylsilylamine (82475-57-8) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → bis(2-(diphenylphosphino)ethyl)amine hydrochloride (66534-97-2)

Guidance literature:

chloro-diphenylphosphine; With lithium; In tetrahydrofuran; at 0 - 20 ℃; for 72h;

N,N-bis(2-chloroethyl)-1,1,1-trimethylsilylamine; In tetrahydrofuran; at 0 ℃; for 1h; Reflux;

upstream raw materials:

bis-(2-chloroethyl)amine hydrochloride

diphenylphosphane

N,N-bis(2-chloroethyl)-1,1,1-trimethylsilylamine

chloro-diphenylphosphine

Downstream raw materials:

5-(2-oxohexahydrothieno[3,4-d]imidazol-6-yl)pentanoic acid bis(2-diphenylphosphanyl-ethyl)amide

4-[bis(2-diphenylphosphanyl)ethyl]amino-4-oxobutanoic acid

2-(2,5-Dioxo-tetrahydro-furan-3-yl)-N,N-bis-(2-diphenylphosphanyl-ethyl)-acetamide

Sodium; 2-[bis-(2-diphenylphosphanyl-ethyl)-carbamoyl]-benzenesulfonate

Refernces

• 1、 Shaalan, Youssef,Boulton, Lee,Jamieson, Craig. "Ruthenium-catalyzed ester reductions applied to pharmaceutical intermediates". supporting information. p. 2745 - 2751. Retrieved 2020/11/30.
• 2、 -. "TRANSITION METAL ISONITRILE CATALYSTS". Page/Page column 21. . Retrieved 2018/11/22.