1-Phenyl-1H-imidazo[4,5-c]pyridine

Base Information

• Chemical Name: 1-Phenyl-1H-imidazo[4,5-c]pyridine
• CAS No.: 61532-35-2
• Molecular Formula: C12H9N3
• Molecular Weight: 195.224
• DSSTox Substance ID: DTXSID00416162
• ChEMBL ID: CHEMBL450929
• Mol file: 61532-35-2.mol

Synonyms:1-Phenyl-1H-imidazo[4,5-c]pyridine;61532-35-2;1-phenylimidazo[4,5-c]pyridine;1-Phenylbenzimidazole deriv. 74;BDBM3857;CHEMBL450929;SCHEMBL10644638;DTXSID00416162;CTOGPLXHZSSJBE-UHFFFAOYSA-N;MFCD03674877;AKOS024285115;1h-imidazo[4,5-c]pyridine,1-phenyl-;FT-0767256;EN300-117992;F52557;1-Phenylimidazo-1H-imidazo[4,5-c]pyridine Hydrochloride;Z1436185652

Chemical Property of 1-Phenyl-1H-imidazo[4,5-c]pyridine

Chemical Property:

• PSA: 30.71000
• LogP: 2.42050
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 195.079647300
• Heavy Atom Count: 15
• Complexity: 213

Purity/Quality:

99% ^*data from raw suppliers

1-Phenyl-1H-imidazo[4,5-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)N2C=NC3=C2C=CN=C3

Technology Process of 1-Phenyl-1H-imidazo[4,5-c]pyridine

There total 7 articles about 1-Phenyl-1H-imidazo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

Imidazo<4,5-c>pyridin (272-97-9,170245-15-5) → 3-phenyl-3H-imidazo[4,5-c]pyridine (1393178-04-5) + 1-phenyl-1H-imidazo[4,5-c]pyridine (61532-35-2)

Guidance literature:

With copper(I) oxide; 8-quinolinol; caesium carbonate; In dimethyl sulfoxide; at 140 ℃; for 1h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/acs.jmedchem.6b00989

Reference yield:

4-(N-phenylamino)-3-nitropyridine (35750-90-4) → 1-phenyl-1H-imidazo[4,5-c]pyridine (61532-35-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 5 percent Pd/C / methanol / 3 h

2: 2-methoxy-ethanol / 3 h / Heating

With hydrogen; palladium on activated charcoal; In methanol; 2-methoxy-ethanol;

DOI:10.1021/jm9804681

Reference yield:

4-chloro-3-nitropyridine (13091-23-1) → 1-phenyl-1H-imidazo[4,5-c]pyridine (61532-35-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 41 percent / aq. HCl / 2-methoxy-ethanol / 18 h / Heating

2: H₂ / 5 percent Pd/C / methanol / 3 h

3: 2-methoxy-ethanol / 3 h / Heating

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; 2-methoxy-ethanol;

DOI:10.1021/jm9804681

upstream raw materials:

formamidine acetic acid

3-amino-4-(phenylamino)pyridine

4-(N-phenylamino)-3-nitropyridine

4-chloro-3-nitropyridine

Downstream raw materials:

C₁₂H₉N₃O

1-phenyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine

1-Phenyl-1,3-dihydro-imidazo[4,5-c]pyridine-2-thione

Refernces

• 1、 -. "P2X7 MODULATORS". Paragraph 0270; 0271. . Retrieved 2014/09/29.
• 2、 Palmer, Brian D.. "Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor". . p. 5457 - 5465. Retrieved 2007/10/03.