2-Phenyloxetane

Base Information

• Chemical Name: 2-Phenyloxetane
• CAS No.: 4436-23-1
• Molecular Formula: C9H10O
• Molecular Weight: 134.178
• Hs Code.: 2932999099
• Mol file: 4436-23-1.mol

Synonyms:phenyl-2 oxetanne;2-phenyloxatane;2-phenyl-[1,2]oxaphospholane;dl-2-phenyloxetane;phenyl-2-oxetane;phenyl-2 oxaphospholane-1,2;2-phenyl-2-phenyl-1,2-oxaphospholane;2-Phenyl-1,2-oxaphospholan;2-phenyl-oxetane;1,2-Oxaphospholane,2-phenyl;1,2-oxaphospholane;

Chemical Property of 2-Phenyloxetane

Chemical Property:

• PSA: 9.23000
• LogP: 2.14800
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Phenyloxetane 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Phenyloxetane

There total 17 articles about 2-Phenyloxetane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-chloro-1-phenyl-propan-1-ol (18776-12-0,125712-82-5) → 2-phenyloxetane (4436-23-1)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 25 ℃; for 4h;

DOI:10.1039/c1cc13670d

Reference yield: 70.0%

styrene oxide (96-09-3) + trimethylsulfoxonium iodide (1774-47-6) → 2-phenyloxetane (4436-23-1)

Guidance literature:

trimethylsulfoxonium iodide; With potassium tert-butylate; In tert-butyl alcohol; at 50 ℃; for 1h;

styrene oxide; In tert-butyl alcohol; at 50 ℃; for 72h; Further stages.;

DOI:10.1021/jo020179r

Reference yield: 63.0%

3-bromo-1-phenyl-1-propanol (100306-31-8,100306-32-9,34052-63-6) → 2-phenyloxetane (4436-23-1)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1002/adsc.201901665

upstream raw materials:

styrene oxide

N,N-(dimethylamino)-methylphenylsulfoxonium tetrafluoroborate

1-phenyl-1,3-propanediol

3-chloro-1-phenyl-propan-1-ol

Downstream raw materials:

3-hydroxy-1-phenylpropan-1-one

(+/-)-1-acetoxy-3-chloro-3-phenylpropane

(2E)-3-phenyl-2-propen-1-ol

Refernces

• 1、 Leung, Vincent Ming-Yau,Gieuw, Matthew H.,Ke, Zhihai,Yeung, Ying-Yeung. "Intermolecular Electrophilic Bromoesterification and Bromoetherification of Unactivated Cyclopropanes". supporting information. p. 2039 - 2044. Retrieved 2020/04/20.
• 2、 Loman, Jacob. J.,Carnaghan, Emma R.,Hamlin, Trevor A.,Ovian, John M.,Kelly, Christopher B.,Mercadante, Michael A.,Leadbeater, Nicholas E.. "A combined computational and experimental investigation of the oxidative ring-opening of cyclic ethers by oxoammonium cations". supporting information. p. 3883 - 3888. Retrieved 2016/05/24.